Mussel bioinspired, silver-coated and insulin-loaded mesoporous polydopamine nanoparticles reinforced hyaluronate-based fibrous hydrogel for potential diabetic wound healing

被引：21

作者：

Ullah, Salim ^{[1
,2
]}

Hussain, Zahid ^{[1
,2
]}

Ullah, Ismat ^{[2
]}

Wang, Li ^{[1
,2
]}

Mehmood, Shah ^{[1
,2
]}

Liu, Yuanshan ^{[1
,2
]}

Mansoorianfar, Mojtaba ^{[2
]}

Liu, Xingzhu ^{[2
]}

Ma, Fanshu ^{[2
]}

Pei, Renjun ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China USTC, Sch Nanotech & Nanob, Hefei 230026, Peoples R China

[2] Chinese Acad Sci, Suzhou Inst Nanotech & Nanob SINANO, CAS Key Lab Nanobio Interface, Suzhou 215123, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 247卷

基金：

中国国家自然科学基金;

关键词：

Polydopamine; Mesoporous nanoparticles; Insulin; Hyaluronic acid; Fibrous hydrogel; Diabetic wound healing; GREEN SYNTHESIS; ACID HYDROGELS; ANTIBACTERIAL; SCAFFOLDS;

D O I：

10.1016/j.ijbiomac.2023.125738

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes wounds take longer to heal due to extended inflammation, decreased angiogenesis, bacterial infection, and oxidative stress. These factors underscore the need for biocompatible and multifunctional dressings with appropriate physicochemical and swelling properties to accelerate wound healing. Herein, insulin (Ins)-loaded, and silver (Ag) coated mesoporous polydopamine (mPD) nanoparticles were synthesized (Ag@Ins-mPD). The nanoparticles were dispersed into polycaprolactone/methacrylated hyaluronate aldehyde dispersion, electrospun to form nanofibers, and then photochemically crosslinked to form a fibrous hydrogel. The nanoparticle, fibrous hydrogel, and nanoparticle-reinforced fibrous hydrogel were characterized for their morphological, mechanical, physicochemical, swelling, drug-release, antibacterial, antioxidant, and cytocompatibility properties. The diabetic wound reconstruction potential of nanoparticle-reinforced fibrous hydrogel was studied using BALB/c mice. The results indicated that Ins-mPD acted as a reductant to synthesize Ag nanoparticles on their surface, held antibacterial and antioxidant potential, and their mesoporous properties are crucial for insulin loading and sustained release. The nanoparticle-reinforced scaffolds were uniform in architecture, porous, mechanically stable, showed good swelling, and possessed superior antibacterial, and cell-responsive properties. Furthermore, the designed fibrous hydrogel scaffold demonstrated good angiogenic, anti-inflammatory, increased collagen deposition, and faster wound repair capabilities, therefore, it could be used as a potential candidate for diabetic wound treatment.

引用

页数：13