An unusual presentation of bilateral optic pathway glioma in Crouzon Syndrome

被引：0

作者：

Na, Brian ^{[1
,2
,3
]}

Wang, Anthony C. ^{[3
,4
]}

Watterson, Christopher Travis ^{[5
]}

Martinez-Agosto, Julian ^{[6
,7
,8
]}

Saitta, Sulagna ^{[6
,7
]}

Dutra-Clarke, Marina ^{[7
]}

Bhansali, Franceska ^{[7
]}

Pineles, Stacy L. ^{[9
]}

Chang, Vivian Y. ^{[3
,10
,11
]}

Shah, Veeral S. ^{[12
]}

de Blank, Peter ^{[13
]}

机构：

[1] UCLA, Dept Neurol, UCLA Neurooncol Program, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] UCLA, Dept Mol & Med Pharmacol, David Geffen Sch Med, Los Angeles, CA USA

[3] UCLA, Jonsson Comprehens Canc Ctr, Los Angeles, CA USA

[4] UCLA, Dept Neurosurg, Div Pediat Neurosurg, David Geffen Sch Med, Los Angeles, CA USA

[5] UCLA, Dept Radiol, David Geffen Sch Med, Los Angeles, CA USA

[6] UCLA, Dept Human Genet, David Geffen Sch Med, Los Angeles, CA USA

[7] UCLA, Dept Pediat, Div Genet, David Geffen Sch Med, Los Angeles, CA USA

[8] UCLA, Dept Psychiat, David Geffen Sch Med, Los Angeles, CA USA

[9] UCLA, Dept Ophthalmol, David Geffen Sch Med, Los Angeles, CA USA

[10] UCLA, Dept Pediat, Div Pediat Hematol Oncol, David Geffen Sch Med, Los Angeles, CA USA

[11] UCLA, Childrens Discovery & Innovat Inst, David Geffen Sch Med, Los Angeles, CA USA

[12] Univ Cincinnati, Dept Ophthalmol, Div Pediat Neurol, Coll Med, Cincinnati, OH USA

[13] Univ Cincinnati, Cure Starts Now Brain Tumor Ctr, Div Oncol, Coll Med, Cincinnati, OH USA

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2023年 / 40卷 / 08期

关键词：

Crouzon; genetics; neuro-oncology; ophthalmology; optic pathway glioma; MUTATION; GROWTH; CHILDREN;

D O I：

10.1080/08880018.2023.2201264

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Crouzon Syndrome is a genetic craniosynostosis disorder associated with a high risk of ophthalmologic sequelae secondary to structural causes. However, ophthalmologic disorders due to intrinsic nerve aberrations in Crouzon Syndrome have not been described. Optic pathway gliomas (OPGs) are low grade gliomas that are intrinsic to the visual pathway, frequently associated with Neurofibromatosis type 1 (NF-1). OPGs involving both optic nerves without affecting the optic chiasm are rarely seen outside of NF-1. We report an unusual case of bilateral optic nerve glioma without chiasmatic involvement in a 17-month-old male patient with Crouzon Syndrome without any clinical or genetic findings of NF-1. This case suggests that close ophthalmologic follow up and orbital MRIs may benefit patients with Crouzon Syndrome.

引用

页码：800 / 806

页数：7

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