Dementia prevention in memory clinics: recommendations from the European task force for brain health services

被引：110

作者：

Frisoni, Giovanni B. ^{[1
,2
]}

Altomare, Daniele ^{[1
,2
]}

Ribaldi, Federica ^{[1
,2
]}

Villain, Nicolas ^{[3
,4
]}

Brayne, Carol ^{[5
]}

Mukadam, Naaheed ^{[6
]}

Abramowicz, Marc ^{[2
,7
]}

Barkhof, Frederik ^{[8
,9
]}

Berthier, Marcelo ^{[10
]}

Bieler-Aeschlimann, Melanie ^{[11
,12
]}

Blennow, Kaj ^{[13
]}

Guevara, Andrea Brioschi ^{[11
,14
]}

Carrera, Emmanuel ^{[2
,15
]}

Chetelat, Gael ^{[16
]}

Csajka, Chantal ^{[17
,18
]}

Demonet, Jean-Francois ^{[11
,19
]}

Dodich, Alessandra ^{[20
]}

Garibotto, Valentina ^{[21
,22
]}

Georges, Jean ^{[23
]}

Hurst, Samia ^{[24
]}

Jessen, Frank ^{[25
,26
,27
,28
]}

Kivipelto, Miia ^{[29
,30
,31
,32
]}

Llewellyn, David J. ^{[33
,34
]}

McWhirter, Laura ^{[35
]}

Milne, Richard ^{[5
,36
]}

Minguillon, Carolina ^{[37
,38
,39
]}

Miniussi, Carlo ^{[20
,40
]}

LuisMolinuevo, Jose ^{[37
,41
]}

Nilsson, Peter M. ^{[42
,43
]}

Noyce, Alastair ^{[44
]}

Ranson, Janice M. ^{[45
]}

Grau-Rivera, Oriol ^{[37
]}

Schott, Jonathan M. ^{[45
]}

Solomon, Alina ^{[32
,46
,47
]}

Stephen, Ruth ^{[46
]}

van der Flier, Wiesje ^{[48
,49
,50
]}

van Duijn, Cornelia ^{[51
,52
,53
]}

Vellas, Bruno ^{[54
]}

Visser, Leonie N. C. ^{[29
,55
]}

Cummings, Jeffrey L. ^{[56
]}

Scheltens, Philip ^{[48
,57
]}

Ritchie, Craig ^{[58
]}

Dubois, Bruno ^{[3
,4
]}

机构：

[1] Univ Hosp, Dept Rehabil & Geriatr, Memory Ctr, Geneva, Switzerland

[2] Univ Geneva, Geneva, Switzerland

[3] Sorbonne Univ, Grp Hosp Pitie Salpetriere, Inst Memoire & Maladie Alzheimer, IM2A, Paris, France

[4] INSERM, UMR S975, Inst Cerveau & Moelle Epiniere, Paris, France

[5] Univ Cambridge, Cambridge Publ Hlth, Cambridge, England

[6] UCL, Div Psychiat, London, England

[7] Univ Hosp, Diagnost Dept, Genet Med, Geneva, Switzerland

[8] Univ Amsterdam, Med Ctr, Radiol & Nucl Med, Amsterdam, Netherlands

[9] UCL, Queen Sq Inst Neurol, London, England

[10] Univ Malaga, Unit Cognit Neurol & Aphasia, CIMES, Malaga, Spain

[11] Univ Hosp Lausanne CHUV, Dept Clin Neurosci, Leenaards Memory Ctr, Lausanne, Switzerland

[12] Univ Hosp Lausanne CHUV, Infect Dis Serv, Lausanne, Switzerland

[13] Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Neurosci & Physiol, Clin Neurochem Lab, Molndal, Sweden

[14] Univ Geneva, Fac Psychol & Educ Sci, Geneva, Switzerland

[15] Univ Hosp, Dept Clin Neurosci, Stroke Ctr, Geneva, Switzerland

[16] Normandie Univ, PhIND Physiopathol & Imaging Neurol Disorders, INSERM, Cyceron,UNICAEN,U1237, Caen, France

[17] Univ Hosp, Ctr Res & Innovat Clin Pharmaceut Sci, Lausanne, Switzerland

[18] Univ Lausanne, Lausanne, Switzerland

[19] Univ Hosp Toulouse, INSERM, French Clin Res Infrastruct Network, Toulouse, France

[20] Univ Trento, Ctr Mind Brain Sci CIMeC, Rovereto, Italy

[21] Univ Hosp Geneva, Div Nucl Med & Mol Imaging, Geneva, Switzerland

[22] Univ Geneva, NIMTLab, Geneva, Switzerland

[23] Alzheimer Europe, Luxembourg, Luxembourg

[24] Univ Geneva, Inst Eth Hist & Humanities, Fac Med, Geneva, Switzerland

[25] Univ Cologne, Dept Psychiat, Fac Med, Cologne, Germany

[26] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[27] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[28] Univ Cologne, Fac Med, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

[29] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Clin Geriatr, Stockholm, Sweden

[30] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[31] Karolinska Univ Hosp, Theme Aging, Stockholm, Sweden

[32] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England

[33] Univ Exeter, Coll Med & Hlth, Exeter, Devon, England

[34] Alan Turing Inst, Exeter, Devon, England

[35] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[36] Wellcome Connecting Sci, Engagement & Soc, Hinxton, England

[37] Pasqual Maragall Fdn, BBRC, Barcelona, Spain

[38] Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain

[39] CIBER Fragilidad & Envejecimiento Saludable CIBER, Madrid, Spain

[40] Univ Trento, Ctr Med Sci CISMed, Rovereto, Italy

[41] H Lundbeck & Co AS, Copenhagen, Denmark

[42] Lund Univ, Dept Clin Sci, Lund, Sweden

[43] Skane Univ Hosp, Dept Internal Med, Malmo, Sweden

[44] Queen Mary Univ London, Prevent Neurol Unit, Wolfson Inst Populat Hlth, London, England

[45] UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

[46] Univ Eastern Finland, Inst Clin Med, Kuopio, Finland

[47] Karolinska Inst, Div Clin Geriatr, NVS, Stockholm, Sweden

[48] Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam, Netherlands

[49] Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands

[50] Vrije Univ Amsterdam, Amsterdam UMC, VUmc, Epidemiol & Data Sci, Amsterdam, Netherlands

来源：

LANCET REGIONAL HEALTH-EUROPE | 2023年 / 26卷

基金：

英国医学研究理事会; 瑞士国家科学基金会;

关键词：

Dementia; Prevention; Memory clinic; Risk assessment; Risk communication; Risk reduction; Cognitive enhancement; ALZHEIMERS-DISEASE; RISK REDUCTION; INTERVENTION; COGNITION; NETWORK;

D O I：

10.1016/j.lanepe.2022.100576

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence sup-ports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.Copyright (c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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