Detection of some synthetic cannabinoids using GC-PCI-MS/MS: Comparison between isobutane and ammonia as reagent gases

被引：4

作者：

Ahmed, Hatem ^{[1
]}

Mohammed, Khaled ^{[1
]}

Mujeebuddin, S. ^{[1
]}

机构：

[1] Naif Arab Univ Secur Sci, Coll Criminal Justice, Dept Forens Sci, Riyadh, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2023年 / 490卷

关键词：

Synthetic cannabinoids; Isobutane; Ammonia; GC-MS; MS; Positive chemical ionization; Protonated molecule; POLYBROMINATED DIPHENYL ETHERS; PRESSURE CHEMICAL-IONIZATION; VOLATILE ORGANIC-COMPOUNDS; SPECTROMETRY PTR-MS; MASS-SPECTROMETRY; IDENTIFICATION;

D O I：

10.1016/j.ijms.2023.117063

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

This study was conducted to investigate the ionization and fragmentation behavior of some synthetic cannabi-noids (SCs) by examining the formation of their product ions using reagent gases having different proton af-finities. Ammonia (NH3) and isobutane (i-C4H10) were employed as reagent gases in positive chemical ionization (PCI) mode using gas chromatography-tandem mass spectrometry (GC-PCI-MS/MS) to qualitatively detect SCs. Under usual operational conditions, the intensity of responses in terms of either ion abundances or peak areas obtained for protonated molecules is significantly influenced by the reagent gases. Ammonia produced two to three times greater responses than isobutane. Additionally, the results showed that the NH3-CI and i-C4H10-CI spectra do not contain the adduct ions for these SCs.

引用

页数：10

共 31 条

[1] Quantitative analysis of 39 polybrominated diphenyl ethers by isotope dilution GC/low-resolution MS [J].

Ackerman, LK ;

Wilson, GR ;

Simonich, SL .

ANALYTICAL CHEMISTRY, 2005, 77 (07) :1979-1987

[2] Accretion Product Formation from Ozonolysis and OH Radical Reaction of α-Pinene: Mechanistic Insight and the Influence of Isoprene and Ethylene [J].

Berndt, Torsten ;

Mender, Bernhard ;

Scholz, Wiebke ;

Fischer, Lukas ;

Herrmann, Hartmut ;

Kulmala, Markku ;

Hansel, Armin .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 52 (19) :11069-11077

[3] Accretion Product Formation from Self- and Cross-Reactions of RO2 Radicals in the Atmosphere [J].

Berndt, Torsten ;

Scholz, Wiebke ;

Mentler, Bernhard ;

Fischer, Lukas ;

Herrmann, Hartmut ;

Kulmala, Markku ;

Hansel, Armin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (14) :3820-3824

[4] Low-pressure chemical ionization in ion trap mass spectrometry [J].

Bouchonnet, S ;

Libong, D ;

Sablier, M .

EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2004, 10 (04) :509-521

[5] Structural characterization of the new synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA [J].

Bovens, Michael ;

Bissig, Christian ;

Staeheli, Sandra N. ;

Poetzsch, Michael ;

Pfeiffer, Bernhard ;

Kraemer, Thomas .

FORENSIC SCIENCE INTERNATIONAL, 2017, 281 :98-105

[6] NH4+ Association and Proton Transfer Reactions With a Series of Organic Molecules [J].

Canaval, Eva ;

Hyttinen, Noora ;

Schmidbauer, Benjamin ;

Fischer, Lukas ;

Hansel, Armin .

FRONTIERS IN CHEMISTRY, 2019, 7

[7] Gas Chromatography/Atmospheric Pressure Chemical Ionization-Time of Flight Mass Spectrometry: Analytical Validation and Applicability to Metabolic Profiling [J].

Carrasco-Pancorbo, Alegria ;

Nevedomskaya, Ekaterina ;

Arthen-Engeland, Thomas ;

Zey, Thomas ;

Zurek, Gabriela ;

Baessmann, Carsten ;

Deelder, Andre M. ;

Mayboroda, Oleg A. .

ANALYTICAL CHEMISTRY, 2009, 81 (24) :10071-10079

[8] HIGH AND LOW-ENERGY COLLISION MASS-SPECTROMETRY MASS-SPECTROMETRY OF AZA AND AMINO POLYNUCLEAR AROMATIC-COMPOUNDS IN COAL-DERIVED LIQUIDS [J].

CIUPEK, JD ;

ZAKETT, D ;

COOKS, RG ;

WOOD, KV .

ANALYTICAL CHEMISTRY, 1982, 54 (13) :2215-2219

[9] Optimization of congener-specific analysis of 40 polybrominated diphenyl ethers by gas chromatography/mass spectrometry [J].

Eljarrat, E ;

Lacorte, S ;

Barceló, D .

JOURNAL OF MASS SPECTROMETRY, 2002, 37 (01) :76-84

[10]

Harrison AG., 2017, Chemical Ionization Mass Spectrometry, DOI [10.1201/9781315139128, DOI 10.1201/9781315139128]

← 1 2 3 4 →