The biogenesis, biological functions and modification of Circular RNAs

被引:20
作者
Liu, Sen [1 ,2 ]
Guo, Xiang Yu [1 ,2 ]
Shang, Qing Juan [3 ,4 ]
Gao, Peng [1 ,2 ,5 ,6 ]
机构
[1] Shandong Univ, Sch Basic Med Sci, Dept Pathol, Key Lab Expt Teratol,Minist Educ, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[3] Linyi Peoples Hosp, Dept Pathol, Linyi, Peoples R China
[4] Jinan Wen Hua Xi Rd 44, Jinan, Peoples R China
[5] Shandong Univ, Key Lab Expt Teratol, Minist Educ, Jinan Wen Hua Xi Rd 44, Jinan 250012, Peoples R China
[6] Shandong Univ, Sch Basic Med Sci, Dept Pathol, Jinan Wen Hua Xi Rd 44, Jinan 250012, Peoples R China
基金
中国国家自然科学基金;
关键词
Circular RNAs; Biogenesis; Biological functions; Modification; MESSENGER-RNA; BINDING PROTEIN; TRANSLATION; DEGRADATION; PROGRESSION; EXPRESSION; TRANSCRIPTION; LANDSCAPE; APOPTOSIS; ABUNDANT;
D O I
10.1016/j.yexmp.2023.104861
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Circular RNAs are covalently closed and non-coding in eukaryotes, which have tissue-specific and temporal -specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self -translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-transcriptional modification, can affect the translation, localization, and degradation of circular RNAs. Cutting-edge research into circular RNAs have benefitted from the development of high-throughput sequencing technology. Further-more, the expansion of novel research methods has promoted progress into circular RNA research.
引用
收藏
页数:8
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