Rat bone marrow mesenchymal stem cells induced by rrPDGF-BB promotes bone regeneration during distraction osteogenesis
被引:7
作者:
Wu, Shuo
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机构:
Xinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Wu, Shuo
[1
]
Zhang, Lijie
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Xinjiang Med Univ, Dept Neurol, Affiliated Hosp 2, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Zhang, Lijie
[2
]
Zhang, Ruidan
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机构:
Guangdong New Omega Med Ctr, Guangzhou, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Zhang, Ruidan
[3
]
Yang, Kang
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机构:
Hand & Foot Microsurg Third Peoples Hosp Xinjiang, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Yang, Kang
[4
]
Wei, Qin
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Xinjiang Med Univ, Anim Expt Ctr, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Wei, Qin
[5
]
Jia, Qiyu
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Xinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Jia, Qiyu
[1
]
Guo, Jian
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Xinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Guo, Jian
[1
]
Ma, Chuang
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Xinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R ChinaXinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
Ma, Chuang
[1
]
机构:
[1] Xinjiang Med Univ, Dept Microrepair & Reconstruct, Affiliated Hosp 1, Urumqi, Peoples R China
[2] Xinjiang Med Univ, Dept Neurol, Affiliated Hosp 2, Urumqi, Peoples R China
[3] Guangdong New Omega Med Ctr, Guangzhou, Peoples R China
[4] Hand & Foot Microsurg Third Peoples Hosp Xinjiang, Urumqi, Peoples R China
[5] Xinjiang Med Univ, Anim Expt Ctr, Urumqi, Peoples R China
Background: In the clinical treatment of large bone defects, distraction osteogenesis can be used. However, some patients may suffer from poor bone regeneration, or even delayed healing or non-union. Problems with the aggregation and proliferation of primary osteoblasts, or problems with the differentiation of primary osteoblasts will lead to poor bone regeneration. Therefore, supplementing exogenous primary osteoblasts and growth factors when using distraction osteogenesis may be a treatment plan with great potential.Methods: Bone marrow mesenchymal stem cells (BMSCs) were extracted from rats and cultured. Subsequently, Recombinant Rat Platelet-derived Growth Factor BB (rrPDGF-BB) was used to induce bone marrow mesenchymal stem cells. At the same time, male adult rats were selected to make the right femoral distraction osteogenesis model. During the mineralization period, phosphate buffer salt solution (control group), non-induction bone marrow mesenchymal stem cells (group 1) and recombinant rat platelet-derived growth factor BB intervened bone marrow mesenchymal stem cells (group 2) were injected into the distraction areas of each group. Then, the experimental results were evaluated with imaging and histology. Statistical analysis of the data showed that the difference was statistically significant if p < 0.05.Results: After intervention with recombinant rat platelet-derived growth factor BB on bone marrow mesenchymal stem cells, the cell morphology changed into a thin strip. After the cells were injected in the mineralization period, the samples showed that the callus in group 2 had greater hardness and the color close to the normal bone tissue; X-ray examination showed that there were more new callus in the distraction space of group 2; Micro-CT examination showed that there were more new bone tissues in group 2; Micro-CT data at week eight showed that the tissue volume, bone volume, percent bone volume, bone trabecular thickness, bone trabecular number and bone mineral density in group 2 were the largest, and the bone trabecular separation in group 2 was the smallest. There was a statistical difference between the groups (p < 0.05); HE staining confirmed that group 2 formed more blood vessels and chondrocytes earlier than the control group. At 8 weeks, the bone marrow cavity of group 2 was obvious, and some of them had been fused.Conclusion: The study confirmed that injecting bone marrow mesenchymal stem cellsBB into the distraction space of rats can promote the formation of new bone in the distraction area and promote the healing of distraction osteogenesis.
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
del Rosario, Carlos
Rodriguez-Evora, Maria
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Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Rodriguez-Evora, Maria
Reyes, Ricardo
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机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Univ La Laguna, Inst Biomed Technol ITB, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Reyes, Ricardo
Delgado, Araceli
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机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Univ La Laguna, Inst Biomed Technol ITB, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Delgado, Araceli
Evora, Carmen
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Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Univ La Laguna, Inst Biomed Technol ITB, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
机构:
Karolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Karolinska Inst, Ctr Mol Med, Dept Womens & Childrens Hlth, L8 01, Stockholm, Sweden
Univ Hosp, Stockholm, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Dou, Zelong
Chau, Michael
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机构:
Karolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Karolinska Inst, Ctr Mol Med, Dept Womens & Childrens Hlth, L8 01, Stockholm, Sweden
Univ Hosp, Stockholm, Sweden
Univ Minnesota, Dept Orthoped Surg, Minneapolis, MN USAKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Chau, Michael
Muder, Daniel
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机构:
Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
Falu Lasarett, Dept Orthoped, Lasarettsvagen 10, S-79182 Falun, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Muder, Daniel
Vedung, Torbjorn
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
Aleris Healthcare, Elisabeth Hosp, Uppsala, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Vedung, Torbjorn
Nilsson, Ola
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h-index: 0
机构:
Karolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Karolinska Inst, Ctr Mol Med, Dept Womens & Childrens Hlth, L8 01, Stockholm, Sweden
Univ Hosp, Stockholm, Sweden
Orebro Univ, Sch Med Sci, Orebro, Sweden
Orebro Univ, Dept Pediat, Orebro, Sweden
Univ Hosp, Orebro, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Hamushan, Musha
Cai, Weijie
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Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Cai, Weijie
Zhang, Yubo
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Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhang, Yubo
Lou, Tengfei
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Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Lou, Tengfei
Zhang, Shaoxiang
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Suzhou Origin Med Technol Co Ltd, Suzhou, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhang, Shaoxiang
Zhang, Xiaonong
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机构:
Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhang, Xiaonong
Cheng, Pengfei
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Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Cheng, Pengfei
Zhao, Changli
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Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhao, Changli
Han, Pei
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Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
del Rosario, Carlos
Rodriguez-Evora, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Rodriguez-Evora, Maria
Reyes, Ricardo
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机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Univ La Laguna, Inst Biomed Technol ITB, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Reyes, Ricardo
Delgado, Araceli
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h-index: 0
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Univ La Laguna, Inst Biomed Technol ITB, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Delgado, Araceli
Evora, Carmen
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h-index: 0
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
Univ La Laguna, Inst Biomed Technol ITB, San Cristobal la Laguna 38200, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna 38200, Spain
机构:
Karolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Karolinska Inst, Ctr Mol Med, Dept Womens & Childrens Hlth, L8 01, Stockholm, Sweden
Univ Hosp, Stockholm, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Dou, Zelong
Chau, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Karolinska Inst, Ctr Mol Med, Dept Womens & Childrens Hlth, L8 01, Stockholm, Sweden
Univ Hosp, Stockholm, Sweden
Univ Minnesota, Dept Orthoped Surg, Minneapolis, MN USAKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Chau, Michael
Muder, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
Falu Lasarett, Dept Orthoped, Lasarettsvagen 10, S-79182 Falun, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Muder, Daniel
Vedung, Torbjorn
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
Aleris Healthcare, Elisabeth Hosp, Uppsala, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Vedung, Torbjorn
Nilsson, Ola
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
Karolinska Inst, Ctr Mol Med, Dept Womens & Childrens Hlth, L8 01, Stockholm, Sweden
Univ Hosp, Stockholm, Sweden
Orebro Univ, Sch Med Sci, Orebro, Sweden
Orebro Univ, Dept Pediat, Orebro, Sweden
Univ Hosp, Orebro, SwedenKarolinska Inst, Div Pediat Endocrinol, Stockholm, Sweden
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Hamushan, Musha
Cai, Weijie
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Cai, Weijie
Zhang, Yubo
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h-index: 0
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhang, Yubo
Lou, Tengfei
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h-index: 0
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Lou, Tengfei
Zhang, Shaoxiang
论文数: 0引用数: 0
h-index: 0
机构:
Suzhou Origin Med Technol Co Ltd, Suzhou, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhang, Shaoxiang
Zhang, Xiaonong
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhang, Xiaonong
Cheng, Pengfei
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Cheng, Pengfei
Zhao, Changli
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China
Zhao, Changli
Han, Pei
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R ChinaShanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Orthopaed Dept, Shanghai 200233, Peoples R China