Prognostic significance of natural products against multidrug tumor resistance

被引：17
作者：
Garg, Pankaj [1 ]
Garg, Rachana [2 ,3 ]
Horne, David [3 ,4 ]
Awasthi, Sanjay [5 ]
Salgia, Ravi [3 ,6 ]
Singhal, Sharad S. [3 ,6 ]
机构：
[1] GLA Univ, Dept Chem, Mathura 281406, Uttar Pradesh, India
[2] Beckman Res Inst City Hope, Comprehens Canc Ctr, Dept Surg, Duarte, CA 91010 USA
[3] Natl Med Ctr, Duarte, CA 91010 USA
[4] Beckman Res Inst City Hope, Comprehens Canc Ctr, Dept Mol Med, Duarte, CA 91010 USA
[5] CTMH Doctors Hosp, Cayman Hlth, KY1-1104, George Town, Grand Cayman, Cayman Islands
[6] Beckman Res Inst City Hope, Comprehens Canc Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA
来源：
CANCER LETTERS | 2023年 / 557卷
基金：
美国国家卫生研究院;
关键词：
Chemoprevention; Natural products; Chemotherapeutic drugs; Drug resistance; BREAST-CANCER CELLS; ESTROGEN-RECEPTOR-ALPHA; HUMAN OVARIAN-CANCER; PROSTATE-CANCER; DIALLYL TRISULFIDE; COLON-CANCER; CYCLE ARREST; IN-VITRO; INDUCED APOPTOSIS; GENE-EXPRESSION;
D O I：
10.1016/j.canlet.2023.216079
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is a pervasive, constantly evolving, and significant public health concern. The number of new cancer cases has risen dramatically in the last decades, making it one of the top causes of poor health and mortality worldwide. Although various treatment strategies, including surgery, radiation, and pharmaceutical therapies, have evolved into more sophisticated, precise methods, there is not much improvement in the cancer-related death toll. Consequently, natural product-based therapeutic discoveries have recently been considered an alternative approach. According to an estimate, one-third of the top twenty medications in today's market have a natural plant-product-based origin. Accordingly, primary prevention is an essential component of worldwide cancer control. This review provides an overview of the mechanisms of action of bioactive ingredients in natural dietary products that may contribute to the prevention and management of multiple malignancies.
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页数：16
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