Urinary microRNA in Diabetic Kidney Disease: A Literature Review

被引:5
作者
Lee, Chin-Chan [1 ]
Chen, Chia-Chun [2 ,3 ]
Hsu, Cheng-Kai [1 ]
Chen, Yih-Ting [1 ]
Chen, Chun-Yu [1 ]
Yang, Kai-Jie [1 ]
Hung, Ming-Jui [4 ]
Wu, I-Wen [1 ,5 ]
机构
[1] Chang Gung Mem Hosp, Dept Nephrol, Keelung 204, Taiwan
[2] Chang Gung Univ, Mol Med Res Ctr, Taoyuan 333, Taiwan
[3] Chang Gung Mem Hosp Linkou, Dept Lab Med, Taoyuan 333, Taiwan
[4] Chang Gung Mem Hosp, Dept Cardiol, Keelung 204, Taiwan
[5] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan
来源
MEDICINA-LITHUANIA | 2023年 / 59卷 / 02期
关键词
diabetes mellitus; diabetic kidney disease; exosomes; microRNA; urinary; GLOMERULAR MESANGIAL CELLS; GLUCOSE-INDUCED APOPTOSIS; RENAL FIBROSIS; COLLAGEN EXPRESSION; PODOCYTE APOPTOSIS; PEDIATRIC-PATIENTS; DOWN-REGULATION; GROWTH-FACTOR; NEPHROPATHY; BIOMARKERS;
D O I
10.3390/medicina59020354
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulations of various cellular biological functions. Previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of Transforming Growth Factor-beta 1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. In this review, we describe the available experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and discuss the future application of microRNA in routine practice.
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页数:12
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