Associations of dietary intakes of vitamins B1 and B3 with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study

The evidence on the association between B vitamins and the risk of CVD is inconclusive. We aimed to examine the association of dietary vitamins B-1 and B-3 intakes with risk of CVD mortality among 58 302 Japanese men and women aged 40-79 years participated in the Japan Collaborative Cohort (JACC) study. The Cox proportional hazard model estimated the hazard ratios (HR) and 95% CI of CVD mortality across increasing energy-adjusted quintiles of dietary vitamins B-1 and B-3 intakes. During 960 225 person-years of follow-up, we documented a total of 3371 CVD deaths. After adjustment for age, sex, and other CVD risk factors, HR of mortality from ischemic heart disease, myocardial infarction, and heart failure in the highest v. lowest vitamin B-1 intake quintiles were 0.57 (95 % CI 0 center dot 40, 0 center dot 80; P-for trend < 0 center dot 01), 0.56 (95 % CI 0 center dot 37, 0 center dot 82; P-for trend < 0 center dot 01), and 0.65 (95 % CI 0 center dot 45, 0 center dot 96; P-for trend = 0 center dot 13). The multivariable HR of myocardial infarction mortality in the highest v. lowest vitamin B-3 intake quintiles was 0.66 (95 % CI 0 center dot 48, 0 center dot 90; P-for trend = 0 center dot 02). Atendency towards a reduced risk of haemorrhagic stroke mortality was observed with a higher dietary intake of vitamin B-3 (HR: 0 center dot 74 (95 % CI 0 center dot 55, 1 center dot 01)) but not vitamin B-1. In conclusion, higher dietary intakes of vitamins B-1 and B-3 were inversely associated with mortality from ischemic heart disease and a higher dietary intake of vitamin B-1 was inversely associated with a reduced risk of mortality from heart failure among Japanese men and women.