Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy

被引:0
作者
Chen, Guan-Yu [1 ,2 ]
Kuo, Kung-Kai [3 ]
Chuang, Shih-Chang [3 ]
Tseng, Kuang-Yi [1 ,2 ]
Wang, Shen-Nien [3 ]
Chang, Wen-Tsan [3 ]
Cheng, Kuang-, I [1 ,2 ]
机构
[1] Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Coll Med, Dept Anesthesiol, Kaohsiung 807, Taiwan
[3] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, Taiwan
来源
MEDICINA-LITHUANIA | 2024年 / 60卷 / 02期
关键词
laparoscopic cholecystectomy; patient control analgesia; post-operative pain; nalbuphine; PAIN; APPENDECTOMY;
D O I
10.3390/medicina60020195
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Optimal opioid analgesia is an excellent analgesia that does not present unexpected adverse effects. Nalbuphine, acting on the opioid receptor as a partial mu antagonist and kappa agonist, is considered a suitable option for patients undergoing laparoscopic surgery. Therefore, we aim to investigate the appropriate dosage of nalbuphine for post-operative pain management in patients with laparoscopic cholecystectomy. Materials and Methods: Patients were randomly categorized into low, medium, and high nalbuphine groups. In each group, a patient control device for post-operative pain control was programed with a low (0.05 mg/kg), medium (0.10 mg/kg), or high (0.20 mg/kg) nalbuphine dose as a loading dose and each bolus dose with a lockout interval of 7 min and without background infusion. Primary and secondary outcomes included the post-operative pain scale and nalbuphine consumption, and episodes of post-operative opioid-related adverse events and satisfactory scores. Results: The low-dosage group presented a higher initial self-reported pain score in comparison to the other two groups for the two hours post-op (p = 0.039) but presented lower nalbuphine consumption than the other two groups for four hours post-op (p = 0.047). There was no significant difference in the analysis of the satisfactory score and adverse events. Conclusions: An appropriate administration of nalbuphine could be 0.1 to 0.2 mg/kg at the initial four hours; this formula could be modified to a lower dosage (0.05 mg/kg) in the post-operative management of laparoscopic cholecystectomy.
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页数:10
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