Cancer stem cells: a target for overcoming therapeutic resistance and relapse

被引：4
作者：
Zhang, Shuo [1 ]
Yang, Rui [2 ]
Ouyang, Yujie [3 ]
Shen, Yang [4 ,5 ,6 ,7 ]
Hu, Lanlin [4 ,5 ,6 ,8 ,9 ]
Xu, Chuan [4 ,5 ,6 ,8 ,9 ]
机构：
[1] Univ Elect Sci & Technol China, Affiliated Canc Hosp, Sichuan Canc Hosp & Inst, Dept Radiat Oncol,Radiat Oncol Key Lab Sichuan Pro, Chengdu 610042, Peoples R China
[2] Chengdu Wenjiang Dist Peoples Hosp, Dept Ultrasound Med, Chengdu 611130, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Acupuncture & Massage Coll, Chengdu 611137, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Oncol, Chengdu 610072, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Canc Inst, Chengdu 610072, Peoples R China
[6] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sichuan Prov Key Lab Human Dis Gene Study, Dept Lab Med, Chengdu 610072, Peoples R China
[7] Macau Univ Sci & Technol, Sch Pharm, Macau 999078, Peoples R China
[8] Yu Yue Pathol Sci Res Ctr, Chongqing 400039, Peoples R China
[9] Jinfeng Lab, Chongqing 401329, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2023年 / 20卷 / 12期
基金：
中国国家自然科学基金;
关键词：
KEYWORDS Cancer stem cells; therapeutic resistance; metabolism; immunology; biomarkers; TUMOR-INITIATING CELLS; REGULATES SELF-RENEWAL; RNA-BINDING PROTEIN; ALDEHYDE DEHYDROGENASE 1A1; LUNG-CANCER; OXIDATIVE-PHOSPHORYLATION; MESENCHYMAL TRANSITION; CD133(+) CELLS; BETA-CATENIN; PROSPECTIVE IDENTIFICATION;
D O I：
10.20892/j.issn.2095-3941.2023.0333
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs. This review provides an overview of the properties, biomarkers, and mechanisms of resistance shown by CSCs. Recent findings on metabolic features, especially fatty acid metabolism and ferroptosis in CSCs, are highlighted, along with promising targeting strategies. Targeting CSCs is a potential treatment plan to conquer cancer and prevent resistance and relapse in cancer treatment.
引用
收藏
页码：985 / 1020
页数：36
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共 458 条
  • [31] Role of Oct4-Sox2 complex decoy oligodeoxynucleotides strategy on reverse epithelial to mesenchymal transition (EMT) induction in HT29-ShE encompassing enriched cancer stem-like cells
    Bigdelou, Zahra
    Mortazavi, Yousef
    Saltanatpour, Zohreh
    Asadi, Zoleykha
    Kadivar, Mehdi
    Johari, Behrooz
    [J]. MOLECULAR BIOLOGY REPORTS, 2020, 47 (03) : 1859 - 1869
  • [32] The molecular signature of AML with increased ALDH activity suggests a stem cell origin
    Blume, Rachel
    Rempel, Eugen
    Manta, Linda
    Saeed, Borhan R.
    Wang, Wenwen
    Raffel, Simon
    Ermakova, Olga
    Eckstein, Volker
    Benes, Vladimir
    Trumpp, Andreas
    Ho, Anthony D.
    Lutz, Christoph
    [J]. LEUKEMIA & LYMPHOMA, 2018, 59 (09) : 2201 - 2210
  • [33] SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
    Boumahdi, Soufiane
    Driessens, Gregory
    Lapouge, Gaelle
    Rorive, Sandrine
    Nassar, Dany
    Le Mercier, Marie
    Delatte, Benjamin
    Caauwe, Amelie
    Lenglez, Sandrine
    Nkusi, Erwin
    Brohee, Sylvain
    Salmon, Isabelle
    Dubois, Christine
    del Marmol, Veronique
    Fuks, Francois
    Beck, Benjamin
    Blanpain, Cedric
    [J]. NATURE, 2014, 511 (7508) : 246 - +
  • [34] Hyaluronan-CD44v3 Interaction with Oct4-Sox2-Nanog Promotes miR-302 Expression Leading to Self-renewal, Clonal Formation, and Cisplatin Resistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma
    Bourguignon, Lilly Y. W.
    Wong, Gabriel
    Earle, Christine
    Chen, Liqun
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (39) : 32800 - 32824
  • [35] Hyaluronan-CD44 Interaction with Protein Kinase Cε Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells
    Bourguignon, Lilly Y. W.
    Spevak, Christina C.
    Wong, Gabriel
    Xia, Weiliang
    Gilad, Eli
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (39) : 26533 - 26546
  • [36] CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    Brown, Rhonda L.
    Reinke, Lauren M.
    Damerow, Mann S.
    Perez, Denise
    Chodosh, Lewis A.
    Yang, Jing
    Cheng, Chonghui
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (03) : 1064 - 1074
  • [37] Identification of CD90 as Putative Cancer Stem Cell Marker and Therapeutic Target in Insulinomas
    Buishand, Floryne O.
    Arkesteijn, Ger J. A.
    Feenstra, Laurien R.
    Oorsprong, Claire W. D.
    Mestemaker, Margiet
    Starke, Achim
    Speel, Ernst-Jan M.
    Kirpensteijn, Jolle
    Mol, Jan A.
    [J]. STEM CELLS AND DEVELOPMENT, 2016, 25 (11) : 826 - 835
  • [38] A STATISTICAL VIEW OF CLINICAL-TRIALS IN CHRONIC HEPATITIS-B
    BURKE, CA
    [J]. JOURNAL OF HEPATOLOGY, 1986, 3 : S261 - S267
  • [39] An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
    Burr, Marian L.
    Sparbier, Christina E.
    Chan, Kah Lok
    Chan, Yih-Chih
    Kersbergen, Ariena
    Lam, Enid Y. N.
    Azidis-Yates, Elizabeth
    Vassiliadis, Dane
    Bell, Charles C.
    Gilan, Omer
    Jackson, Susan
    Tan, Lavinia
    Wong, Stephen Q.
    Hollizeck, Sebastian
    Michalak, Ewa M.
    Siddle, Hannah, V
    McCabe, Michael T.
    Prinjha, Rab K.
    Guerra, Glen R.
    Solomon, Benjamin J.
    Sandhu, Shahneen
    Dawson, Sarah-Jane
    Beavis, Paul A.
    Tothill, Richard W.
    Cullinane, Carleen
    Lehner, Paul J.
    Sutherland, Kate D.
    Dawson, Mark A.
    [J]. CANCER CELL, 2019, 36 (04) : 385 - +
  • [40] LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer
    Cao, Hao-Zhe
    Liu, Xiao-Fang
    Yang, Wen-Ting
    Chen, Qing
    Zheng, Peng-Sheng
    [J]. CELL DEATH & DISEASE, 2017, 8 : e3039 - e3039
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