Cancer stem cells: a target for overcoming therapeutic resistance and relapse

被引：4
作者：
Zhang, Shuo [1 ]
Yang, Rui [2 ]
Ouyang, Yujie [3 ]
Shen, Yang [4 ,5 ,6 ,7 ]
Hu, Lanlin [4 ,5 ,6 ,8 ,9 ]
Xu, Chuan [4 ,5 ,6 ,8 ,9 ]
机构：
[1] Univ Elect Sci & Technol China, Affiliated Canc Hosp, Sichuan Canc Hosp & Inst, Dept Radiat Oncol,Radiat Oncol Key Lab Sichuan Pro, Chengdu 610042, Peoples R China
[2] Chengdu Wenjiang Dist Peoples Hosp, Dept Ultrasound Med, Chengdu 611130, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Acupuncture & Massage Coll, Chengdu 611137, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Oncol, Chengdu 610072, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Canc Inst, Chengdu 610072, Peoples R China
[6] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sichuan Prov Key Lab Human Dis Gene Study, Dept Lab Med, Chengdu 610072, Peoples R China
[7] Macau Univ Sci & Technol, Sch Pharm, Macau 999078, Peoples R China
[8] Yu Yue Pathol Sci Res Ctr, Chongqing 400039, Peoples R China
[9] Jinfeng Lab, Chongqing 401329, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2023年 / 20卷 / 12期
基金：
中国国家自然科学基金;
关键词：
KEYWORDS Cancer stem cells; therapeutic resistance; metabolism; immunology; biomarkers; TUMOR-INITIATING CELLS; REGULATES SELF-RENEWAL; RNA-BINDING PROTEIN; ALDEHYDE DEHYDROGENASE 1A1; LUNG-CANCER; OXIDATIVE-PHOSPHORYLATION; MESENCHYMAL TRANSITION; CD133(+) CELLS; BETA-CATENIN; PROSPECTIVE IDENTIFICATION;
D O I：
10.20892/j.issn.2095-3941.2023.0333
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs. This review provides an overview of the properties, biomarkers, and mechanisms of resistance shown by CSCs. Recent findings on metabolic features, especially fatty acid metabolism and ferroptosis in CSCs, are highlighted, along with promising targeting strategies. Targeting CSCs is a potential treatment plan to conquer cancer and prevent resistance and relapse in cancer treatment.
引用
收藏
页码：985 / 1020
页数：36
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