Cancer stem cells: a target for overcoming therapeutic resistance and relapse

被引：4
作者：
Zhang, Shuo [1 ]
Yang, Rui [2 ]
Ouyang, Yujie [3 ]
Shen, Yang [4 ,5 ,6 ,7 ]
Hu, Lanlin [4 ,5 ,6 ,8 ,9 ]
Xu, Chuan [4 ,5 ,6 ,8 ,9 ]
机构：
[1] Univ Elect Sci & Technol China, Affiliated Canc Hosp, Sichuan Canc Hosp & Inst, Dept Radiat Oncol,Radiat Oncol Key Lab Sichuan Pro, Chengdu 610042, Peoples R China
[2] Chengdu Wenjiang Dist Peoples Hosp, Dept Ultrasound Med, Chengdu 611130, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Acupuncture & Massage Coll, Chengdu 611137, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Oncol, Chengdu 610072, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Canc Inst, Chengdu 610072, Peoples R China
[6] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sichuan Prov Key Lab Human Dis Gene Study, Dept Lab Med, Chengdu 610072, Peoples R China
[7] Macau Univ Sci & Technol, Sch Pharm, Macau 999078, Peoples R China
[8] Yu Yue Pathol Sci Res Ctr, Chongqing 400039, Peoples R China
[9] Jinfeng Lab, Chongqing 401329, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2023年 / 20卷 / 12期
基金：
中国国家自然科学基金;
关键词：
KEYWORDS Cancer stem cells; therapeutic resistance; metabolism; immunology; biomarkers; TUMOR-INITIATING CELLS; REGULATES SELF-RENEWAL; RNA-BINDING PROTEIN; ALDEHYDE DEHYDROGENASE 1A1; LUNG-CANCER; OXIDATIVE-PHOSPHORYLATION; MESENCHYMAL TRANSITION; CD133(+) CELLS; BETA-CATENIN; PROSPECTIVE IDENTIFICATION;
D O I：
10.20892/j.issn.2095-3941.2023.0333
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs. This review provides an overview of the properties, biomarkers, and mechanisms of resistance shown by CSCs. Recent findings on metabolic features, especially fatty acid metabolism and ferroptosis in CSCs, are highlighted, along with promising targeting strategies. Targeting CSCs is a potential treatment plan to conquer cancer and prevent resistance and relapse in cancer treatment.
引用
收藏
页码：985 / 1020
页数：36
相关论文
共 458 条
  • [1] The most reliable surface marker for the identification of colorectal cancer stem-like cells: A systematic review and meta-analysis
    Abbasian, Mahdi
    Mousavi, Elham
    Arab-Bafrani, Zahra
    Sahebkar, Amirhossein
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) : 8192 - 8202
  • [2] Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program
    Aguilar, Esther
    Marin de Mas, Igor
    Zodda, Erika
    Marin, Silvia
    Morrish, Fionnuala
    Selivanov, Vitaly
    Meca-Cortes, Oscar
    Delowar, Hossain
    Pons, Monica
    Izquierdo, Ines
    Celia-Terrassa, Toni
    de Atauri, Pedro
    Centelles, Josep J.
    Hockenbery, David
    Thomson, Timothy M.
    Cascante, Marta
    [J]. STEM CELLS, 2016, 34 (05) : 1163 - 1176
  • [3] Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs
    Ahmad, Aamir
    Maitah, Ma'in Y.
    Ginnebaugh, Kevin R.
    Li, Yiwei
    Bao, Bin
    Gadgeel, Shirish M.
    Sarkar, Fazlul H.
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2013, 6
  • [4] Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells
    Ahmed, Shafiq U.
    Carruthers, Ross
    Gilmour, Lesley
    Yildirim, Salih
    Watts, Colin
    Chalmers, Anthony J.
    [J]. CANCER RESEARCH, 2015, 75 (20) : 4416 - 4428
  • [5] LGR5/R-Spo1/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines
    Akbari, Soheil
    Kunter, Imge
    Azbazdar, Yagmur
    Ozhan, Gunes
    Atabey, Nese
    Karagonlar, Zeynep Firtina
    Erdal, Esra
    [J]. CELLULAR SIGNALLING, 2021, 82
  • [6] SOX2 in cancer stemness: tumor malignancy and therapeutic potentials
    Al Mamun, Mahfuz
    Mannoor, Kaiissar
    Cao, Jun
    Qadri, Firdausi
    Song, Xiaoyuan
    [J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 12 (02) : 85 - 98
  • [7] Prospective identification of tumorigenic breast cancer cells
    Al-Hajj, M
    Wicha, MS
    Benito-Hernandez, A
    Morrison, SJ
    Clarke, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
  • [8] Signaling pathways and microRNAs, the orchestrators of NANOG activity during cancer induction
    Alemohammad, Hajar
    Asadzadeh, Zahra
    Azad, Rohollah Motafakker
    Hemmat, Nima
    Najafzadeh, Basira
    Vasefifar, Parisa
    Najafi, Souzan
    Baradaran, Behzad
    [J]. LIFE SCIENCES, 2020, 260
  • [9] NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype
    Ames, Erik
    Canter, Robert J.
    Grossenbacher, Steven K.
    Mac, Stephanie
    Chen, Mingyi
    Smith, Rachel C.
    Hagino, Takeshi
    Perez-Cunningham, Jessica
    Sckisel, Gail D.
    Urayama, Shiro
    Monjazeb, Arta M.
    Fragoso, Ruben C.
    Sayers, Thomas J.
    Murphy, William J.
    [J]. JOURNAL OF IMMUNOLOGY, 2015, 195 (08) : 4010 - 4019
  • [10] Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells
    An, Hyunsook
    Kim, Ji Young
    Oh, Eunhye
    Lee, Nahyun
    Cho, Youngkwan
    Seo, Jae Hong
    [J]. PLOS ONE, 2015, 10 (11):
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