Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review

被引:3
作者
Rodriguez-Serrano, Luis Miguel [1 ]
Chavez-Hernandez, Maria Elena [1 ]
Laezza, Chiara
机构
[1] Univ Anahuac Mexico, Fac Psicol, Univ Anahuac Ave 46, Lomas Anahuac 52786, Huixquilucan, Mexico
关键词
cannabinoid; 2; receptor; food intake; overweight; systematic review; ENDOCANNABINOID SYSTEM; EATING BEHAVIOR; PALATABLE FOOD; MICE; EXPRESSION; OBESITY; BRAIN; LOCALIZATION; SENSITIVITY; HOMEOSTASIS;
D O I
10.3390/ijms242417516
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The CB2 cannabinoid receptor has been found in brain areas that are part of the reward system and has been shown to play a role in food intake regulation. Herein, we conducted a systematic review of studies assessing the role of the CB2 receptor in food intake regulation. Records from the PubMed, Scopus, and EBSCO databases were screened, resulting in 13 studies that were used in the present systematic review, following the PRISMA guidelines. A risk of bias assessment was carried out using the tool of the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE). The studies analyzed used two main strategies: (1) the intraperitoneal or intracerebroventricular administration of a CB2 agonist/antagonist; and (2) depletion of CB2 receptors via knockout in mice. Both strategies are useful in identifying the role of the CB2 receptor in food intake in standard and palatable diets. The conclusions derived from animal models showed that CB2 receptors are necessary for modulating food intake and mediating energy balance.
引用
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页数:13
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