Altered cortical and subcortical morphometric features and asymmetries in the subjective cognitive decline and mild cognitive impairment

被引:3
作者
Yang, Jin [1 ]
Liang, Lingyan [2 ]
Wei, Yichen [2 ]
Liu, Ying [2 ]
Li, Xiaocheng [2 ]
Huang, Jiazhu [2 ]
Zhang, Zhiguo [3 ,4 ,5 ]
Li, Linling [6 ,7 ]
Deng, Demao [1 ,2 ]
机构
[1] Guangxi Univ, Sch Med, Nanning, Guangxi, Peoples R China
[2] Guangxi Acad Med Sci, Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Radiol, Nanning, Guangxi, Peoples R China
[3] Harbin Inst Technol, Sch Comp Sci & Technol, Shenzhen, Guangdong, Peoples R China
[4] Shenzhen Univ, Marshall Lab Biomed Engn, Shenzhen, Guangdong, Peoples R China
[5] Peng Cheng Lab, Shenzhen, Guangdong, Peoples R China
[6] Shenzhen Univ, Med Sch, Sch Biomed Engn, Shenzhen, Peoples R China
[7] Guangdong Prov Key Lab Biomed Measurements & Ultra, Shenzhen, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
基金
中国国家自然科学基金;
关键词
subjective cognitive decline; mild cognitive impairment; asymmetry index; local gyrification index; hypothalamic subfields; GREY-MATTER ATROPHY; ALZHEIMERS-DISEASE; EPISODIC MEMORY; DEMENTIA; PROGRESSION; BIOMARKER; EDUCATION; DEFICITS; CORTEX; BRAIN;
D O I
10.3389/fneur.2023.1297028
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
IntroductionThis study aimed to evaluate morphological changes in cortical and subcortical regions and their asymmetrical differences in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). These morphological changes may provide valuable insights into the early diagnosis and treatment of Alzheimer's disease (AD).MethodsWe conducted structural MRI scans on a cohort comprising 62 SCD patients, 97 MCI patients, and 70 age-, sex-, and years of education-matched healthy controls (HC). Using Freesurfer, we quantified surface area, thickness, the local gyrification index (LGI) of cortical regions, and the volume of subcortical nuclei. Asymmetry measures were also calculated. Additionally, we explored the correlation between morphological changes and clinical variables related to cognitive decline.ResultsCompared to HC, patients with MCI exhibited predominantly left-sided surface morphological changes in various brain regions, including the transverse temporal gyrus, superior temporal gyrus, insula, and pars opercularis. SCD patients showed relatively minor surface morphological changes, primarily in the insula and pars triangularis. Furthermore, MCI patients demonstrated reduced volumes in the anterior-superior region of the right hypothalamus, the fimbria of the bilateral hippocampus, and the anterior region of the left thalamus. These observed morphological changes were significantly associated with clinical ratings of cognitive decline.ConclusionThe findings of this study suggest that cortical and subcortical morphometric changes may contribute to cognitive impairment in MCI, while compensatory mechanisms may be at play in SCD to preserve cognitive function. These insights have the potential to aid in the early diagnosis and treatment of AD.
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页数:12
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共 77 条
  • [1] Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit
    Aggleton, John P.
    Pralus, Agathe
    Nelson, Andrew J. D.
    Hornberger, Michael
    [J]. BRAIN, 2016, 139 : 1877 - 1890
  • [2] Aggleton JP, 1999, BEHAV BRAIN SCI, V22, P425
  • [3] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Albert, Marilyn S.
    DeKosky, Steven T.
    Dickson, Dennis
    Dubois, Bruno
    Feldman, Howard H.
    Fox, Nick C.
    Gamst, Anthony
    Holtzman, David M.
    Jagust, William J.
    Petersen, Ronald C.
    Snyder, Peter J.
    Carrillo, Maria C.
    Thies, Bill
    Phelps, Creighton H.
    [J]. ALZHEIMERS & DEMENTIA, 2011, 7 (03) : 270 - 279
  • [4] Adjust for Multiple Comparisons? It's Not That Simple
    Althouse, Andrew D.
    [J]. ANNALS OF THORACIC SURGERY, 2016, 101 (05) : 1644 - 1645
  • [5] Grey matter changes on brain MRI in subjective cognitive decline: a systematic review
    Arrondo, Pablo
    Elia-Zudaire, Oscar
    Marti-Andres, Gloria
    Fernandez-Seara, Maria A.
    Riverol, Mario
    [J]. ALZHEIMERS RESEARCH & THERAPY, 2022, 14 (01)
  • [6] Isolated mammillary body involvement on MRI in Wernicke's encephalopathy
    Beh, Shin C.
    Frohman, Teresa C.
    Frohman, Elliot M.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2013, 334 (1-2) : 172 - 175
  • [7] Structural Changes in Thalamic Nuclei Across Prodromal and Clinical Alzheimer's Disease
    Bernstein, Adam S.
    Rapcsak, Steven Z.
    Hornberger, Michael
    Saranathan, Manojkumar
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2021, 82 (01) : 361 - 371
  • [8] Automated segmentation of the hypothalamus and associated subunits in brain MRI
    Billot, Benjamin
    Bocchetta, Martina
    Todd, Emily
    Dalca, Adrian, V
    Rohrer, Jonathan D.
    Iglesias, Juan Eugenio
    [J]. NEUROIMAGE, 2020, 223
  • [9] Central Role of Glucocorticoid Receptors in Alzheimer's Disease and Depression
    Canet, Geoffrey
    Chevallier, Nathalie
    Zussy, Charleine
    Desrumaux, Catherine
    Givalois, Laurent
    [J]. FRONTIERS IN NEUROSCIENCE, 2018, 12
  • [10] The precuneus: a review of its functional anatomy and behavioural correlates
    Cavanna, AE
    Trimble, MR
    [J]. BRAIN, 2006, 129 : 564 - 583