Dioscorea nipponica Makino: A comprehensive review of its chemical composition and pharmacology on chronic kidney disease

被引：2
作者：
Wu, Chenguang [1 ]
Zhang, Rui [1 ]
Wang, Jingjing [1 ]
Chen, Yao [1 ]
Zhu, Wenhui [1 ]
Yi, Xiang [1 ]
Wang, Yan [2 ]
Wang, Lifan [1 ,5 ]
Liu, Peng [3 ,6 ]
Li, Ping [4 ,7 ]
机构：
[1] Heilongjiang Acad Chinese Med Sci, Dept Med, Renal Div, Harbin, Peoples R China
[2] Peking Univ Peoples Hosp, Dept Nephrol, Beijing, Peoples R China
[3] Shunyi Hosp, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China
[4] China Japan Friendship Hosp, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China
[5] 142 Sanfu St, Harbin 150036, Peoples R China
[6] 1 Courtyard Jiansheng St, Beijing, Peoples R China
[7] 2 Yinghua Dongjie, Beijing 100029, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 167卷
基金：
中国国家自然科学基金;
关键词：
Dioscorea nipponica Makino (DNM); Chronic kidney disease (CKD); Oxidative stress; Renal fibrosis; Inflammatory response; CHINESE HERBAL MEDICINE; CORONARY-HEART-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; DOWN-REGULATION; URIC-ACID; RAT MODEL; MITOCHONDRIAL DYSFUNCTION; MOLECULAR-MECHANISMS; RENAL-DISEASE;
D O I：
10.1016/j.biopha.2023.115508
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Chronic kidney disease (CKD) is a widespread ailment that significantly impacts global health. It is characterized by high prevalence, poor prognosis, and substantial healthcare costs, making it a major public health concern. The current clinical treatments for CKD are not entirely satisfactory, leading to a high demand for alternative therapeutic options. Chinese herbal medicine, with its long history, diverse varieties, and proven efficacy, offers a promising avenue for exploration. One such Chinese herbal medicine, Dioscorea nipponica Makino (DNM), is frequently used to treat kidney diseases. In this review, we have compiled studies examining the mechanisms of action of DNM in the context of CKD, focusing on five primary areas: improvement of oxidative stress, inhibition of renal fibrosis, regulation of metabolism, reduction of inflammatory response, and regulation of autophagy.
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页数：11
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