Genetic robustness control of auxin output in priming organ initiation

被引:17
作者
Dai, Yuqiu [1 ]
Luo, Linjie [2 ,3 ]
Zhao, Zhong [1 ]
机构
[1] Univ Sci & Technol China, Chinese Acad Sci Ctr Excellence Mol Plant Sci, Sch Life Sci, Div Life Sci & Med,Minist Educ,Key Lab Cellular Dy, Hefei 230027, Peoples R China
[2] Anhui Normal Univ, Coll Life Sci, Anhui Prov Key Lab Mol Enzymol & Mech Major Dis, Wuhu 241000, Peoples R China
[3] Anhui Normal Univ, Coll Life Sci, Anhui Prov Key Lab Conservat & Exploitat Biol Reso, Wuhu 241000, Peoples R China
基金
中国国家自然科学基金;
关键词
auxin Unlike; organ initiation; DORNROSCHEN-LIKE; spatial gene compensation; robustness control; STEM-CELLS; DORNROSCHEN-LIKE; ARABIDOPSIS; PLANT; CYTOKININ; MERISTEM; EXPRESSION; REQUIREMENT; MONOPTEROS; TRANSPORT;
D O I
10.1073/pnas.2221606120
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Auxin signaling is essential for organ initiation in plants. How genetic robustness controls auxin output during organ initiation is largely unknown. Here, we identified DORNROSCHEN-LIKE (DRNL) as a target of MONOPTEROS (MP) that plays essential roles in organ initiation. We demonstrate that MP physically interacts with DRNL to inhibit cytokinin accumulation by directly activating ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN 6and CYTOKININ OXIDASE 6. DRN, the paralogous gene of DRNL, acts redundantly with DRNL but is not coexpressed with DRNL in the organ founder cells in which DRNL is expressed. We demonstrate that DRNL directly inhibits DRN expression in the peripheral zone, whereas DRN transcripts are ectopically activated in drnl mutants and fully restore the functional deficiency of drnl in organ initiation. Our results provide a mechanistic framework for the robust control of auxin signaling in organ initiation through paralogous gene-triggered spatial gene compensation effects.
引用
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页数:11
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