Aging microglia

被引：44

作者：

Antignano, Ignazio ^{[1
]}

Liu, Yingxiao ^{[1
]}

Offermann, Nina ^{[1
]}

Capasso, Melania ^{[1
]}

机构：

[1] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, Bonn, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2023年 / 80卷 / 05期

关键词：

Microglia; Aging; Neuroinflammation; RNAseq; Human microglia; Senescence; PLURIPOTENT STEM-CELLS; SENESCENT CELLS; OLIGODENDROCYTE GENERATION; COMPLEMENT ACTIVATION; DYSTROPHIC MICROGLIA; METABOLIC FITNESS; NEUROGLIAL CELLS; GENE-EXPRESSION; IMMUNE CELLS; MOUSE MODEL;

D O I：

10.1007/s00018-023-04775-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.

引用

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