The Prognostic Significance of FOXD1 Expression in Head and Neck Squamous Cell Carcinoma

被引：3
作者：
Jiang, Wenmei [1 ]
Li, Yudong [1 ]
Li, Ruiyu [1 ]
Chen, Wenkuan [1 ]
Song, Ming [1 ]
Zhang, Quan [1 ]
Chen, Shuwei [1 ]
机构：
[1] Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, Canc Ctr, Dept Head & Neck Surg,State Key Lab Oncol South Ch, Guangzhou 510060, Peoples R China
来源：
JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 03期
基金：
中国国家自然科学基金;
关键词：
forkhead box D1; head and neck squamous cell carcinoma; clinicopathologic characteristics; survival; TUMOR GENE WT1; TRANSCRIPTION FACTORS; POOR-PROGNOSIS; CANCER; PROLIFERATION; OVEREXPRESSION;
D O I：
10.3390/jpm13030530
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
It has been reported that forkhead box D1 (FOXD1) plays an established role in human early embryonic development and is broadly involved in various malignancies. However, there is limited information regarding FOXD1 expression in head and neck squamous cell carcinoma (HNSCC). This present study aimed to explore the clinical significance of FOXD1 in patients with HNSCC. Tissue microarrays of 334 primary HNSCC patients who underwent surgery between 2008 and 2010 at Sun Yat-sen University Cancer Center were investigated by immunohistochemistry regarding FOXD1 expression. chi(2) test was used to estimate the relationship of FOXD1 expression with clinicopathologic characteristics. Univariate and multivariate analyses were performed to identify FOXD1 expression as an independent prognostic indicator of overall survival (OS) and disease-free survival (DFS). FOXD1 expression is closely associated with postoperative recurrence. HNSCC patients with high FOXD1 expression have poorer prognoses than the low-expression group (p < 0.05). According to multivariate analysis, FOXD1 was an independent prognostic factor for OS and DFS. The results revealed that FOXD1 could be a prognostic factor for HNSCC and might serve as a potential target for novel therapies.
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页数：12
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