Real-life experience with ixekizumab in plaque psoriasis: a multi-center, retrospective, 3-year study

被引：9

作者：

Caldarola, Giacomo ^{[1
,2
,10
]}

Chiricozzi, A. ^{[1
,2
]}

Megna, M. ^{[3
]}

Dapavo, P. ^{[4
]}

Giunta, A. ^{[5
]}

Burlando, M. ^{[6
]}

Malagoli, P. ^{[7
]}

Dini, V ^{[8
]}

Mariani, M. ^{[9
]}

Fabbrocini, G. ^{[3
]}

Quaglino, P. ^{[4
]}

Bianchi, L. ^{[5
]}

Parodi, A. ^{[6
]}

Peris, K. ^{[1
,2
]}

De Simone, C. ^{[1
,2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dipartimento Univ Med & Chirurg Traslazionale, Sect Dermatol, Rome, Italy

[2] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Med & Chirurg, Dermatol Unit, Rome, Italy

[3] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy

[4] Univ Turin, Dept Biomed Sci & Human Oncol, Dermatol Clin 2, Turin, Italy

[5] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[6] Univ Genoa, San Martino Polyclin Hosp, DiSSal Dept Hlth Sci, Sect Dermatol, Genoa, Italy

[7] Azienda Osped San Donato Milanese, Dermatol Unit, Milan, Italy

[8] Univ Pisa, Dept Clin & Expt Med, Dermatol Unit, Pisa, Italy

[9] Univ Dept Hlth Sci & Publ Hlth, Sect Hyg, Rome, Italy

[10] Univ Cattolica Sacro Cuore, Dipartimento Univ Med & Chirurg Traslazionale, Ist Dermatol, Sect Dermatol, Lgo F Vito, I-00135 Rome, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2023年 / 23卷 / 04期

关键词：

Efficacy; ixekizumab; psoriasis; real-life; safety; DRUG SURVIVAL; SAFETY; ADALIMUMAB; EFFICACY;

D O I：

10.1080/14712598.2023.2193288

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

BackgroundConfirmatory data on the long-term effectiveness and safety of ixekizumab in psoriatic patients from real-world studies are needed.ObjectivesThe primary aim was to evaluate the 3-year drug survival of ixekizumab in the treatment of patients with moderate-to-severe plaque psoriasis, in a multicenter real-world setting. The secondary aim was to assess the influence of predictive factors on the drug survival of ixekizumab.MethodsA retrospective analysis was performed on a cohort of patients with chronic plaque psoriasis, who received at least one dose of ixekizumab before December 2018. The drug survival analysis was performed and descriptively analyzed using Kaplan-Meier survival curves. Multivariable Cox regression analyses were carried out including variables considered to be of clinical importance.ResultsA total of 306 patients were enrolled. The overall drug survival at 12, 24, and 36 months of treatment with ixekizumab was 92.11%, 83.85%, and 80.19%, respectively. A higher probability (HR 2.34) of drug withdrawal was found among patients who had already received an anti-IL-17 agent compared with bio-naive patients (p 0.017).ConclusionsWe found that ixekizumab is a biological agent characterized by long-term effectiveness, not influenced by several clinical factors and associated with a good safety profile.

引用

页码：365 / 370

页数：6

共 28 条

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