EFMC: Trends in Medicinal Chemistry and Chemical Biology

被引：7

作者：

Auberson, Yves P. ^{[1
]}

Arimondo, Paola B. ^{[2
]}

Duca, Maria ^{[3
]}

Essig, Sebastian ^{[4
]}

Grether, Uwe ^{[5
]}

Rufer, Arne C. ^{[5
]}

Sbardella, Gianluca ^{[6
]}

Schopfer, Ulrich ^{[7
]}

Torrens, Antoni ^{[8
]}

van Der Stelt, Mario ^{[9
]}

Vauzeilles, Boris ^{[10
]}

Vazquez, Olalla ^{[11
,12
]}

Zhang, Andrew D. X.

机构：

[1] Novartis Inst Biomed Res, Global Discovery Chem, Novartis Campus,WSJ 88-10, CH-4056 Basel, Switzerland

[2] Univ Paris, Inst Pasteur, Dept Epigenet Chem Biol, CNRS,UMR3523,Chem4Life, 28 Rue Dr Roux, F-75015 Paris, France

[3] Univ Cote Azur, CNRS, UMR7272, Inst Chim Nice ICN, Parc Valrose, F-06100 Nice, France

[4] Bayer AG, Res & Dev, Pharmaceut Drug Discovery Sci, Life Sci Technol, Aprather Weg 18a,Gebaude 460,Raum 345, D-42113 Wuppertal, Germany

[5] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Pharm Res & Early Dev, Grenzacherstr 124, CH-4070 Basel, Switzerland

[6] Univ Salerno, Dept Pharm, Epigenet Med Chem Lab, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

[7] Novartis Inst Biomed Res, Chem Biol & Therapeut, Novartis Campus,WSJ 182-Z4-249-14, CH-4056 Basel, Switzerland

[8] ABAC Therapeut SL, Joan XXIII 10, Barcelona 08950, Spain

[9] Leiden Univ, Inst Chem Chem Biol, Gorlaeus Bldg,Room DE3 19,Einsteinweg 55, NL-2333 CC Leiden, Netherlands

[10] Univ Paris Saclay, Discovery Sci, Chem Biol Dept, Inst Chim Subst Nat,UPR 2301, F-91198 Waltham, MA, France

[11] Philipps Univ Marburg, Dept Chem, D-35032 Marburg, Germany

[12] Philipps Univ Marburg, Ctr Synthet Microbiol SYNMIKRO, D-35032 Marburg, Germany

来源：

CHEMBIOCHEM | 2023年

关键词：

chemical biology; computational chemistry; EFMC; medicinal chemistry; trends; TARGETED PROTEIN-DEGRADATION; DRUG DISCOVERY; AMG; 510; INHIBITORS; LIGAND; STRATEGY; IDENTIFICATION; DESIGN; PROBES; CELLS;

D O I：

10.1002/cbic.202200690

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ground-breaking research in disease biology and continuous efforts in method development have uncovered a range of potential new drug targets. Increasingly, the drug discovery process is informed by technologies involving chemical probes as tools. Applications for chemical probes comprise target identification and assessment, as well as the qualification of small molecules as chemical starting points and drug candidates. Progress in probe chemistry has opened the way to novel assay formats and pharmaceutical compound classes. The European Federation of Medicinal Chemistry and Chemical Biology (EFMC) has launched the Chemical Biology Initiative to advance science in the field of medicinal chemistry and chemical biology, while representing all members of this extended scientific community. This review provides an overview of the many important developments in the field of chemical biology that have happened at the lively interface of academic and industrial research.

引用

页数：17

共 230 条

[61] A Comprehensive Mathematical Model for Three-Body Binding Equilibria [J].

Douglass, Eugene F., Jr. ;

Miller, Chad J. ;

Sparer, Gerson ;

Shapiro, Harold ;

Spiegel, David A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (16) :6092-6099

[62] The Chemical Biology-Medicinal Chemistry Continuum: EFMC's Vision [J].

Duca, Maria ;

Gillingham, Dennis ;

Olsen, Christian Adam ;

Sbardella, Gianluca ;

Skaanderup, Philip R. ;

van der Stelt, Mario ;

Vauzeilles, Boris ;

Vazquez, Olalla ;

Auberson, Yves P. .

CHEMBIOCHEM, 2021, 22 (19) :2823-2825

[63]

efmc.info, 2018 EFMC HAS ACT PU

[64]

efmc.info, COMPUTATIONAL CHEM

[65] Optochemical Genetics [J].

Fehrentz, Timm ;

Schoenberger, Matthias ;

Trauner, Dirk .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (51) :12156-12182

[66] 177Lu-PSMA Radioligand Therapy for Prostate Cancer [J].

Fendler, Wolfgang P. ;

Rahbar, Kambiz ;

Herrmann, Ken ;

Kratochwil, Clemens ;

Eiber, Matthias .

JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (08) :1196-1200

[67] The Importance of Collaboration between Industry, Academics, and Nonprofits in Tropical Disease Drug Discovery [J].

Ferrins, Lori ;

Pollastri, Michael P. .

ACS INFECTIOUS DISEASES, 2018, 4 (04) :445-448

[68] Synthetic organic chemistry driven by artificial intelligence [J].

Filipa de Almeida, A. ;

Moreira, Rui ;

Rodrigues, Tiago .

NATURE REVIEWS CHEMISTRY, 2019, 3 (10) :589-604

[69] Phosphine Oxides from a Medicinal Chemist's Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery [J].

Finkbeiner, Peter ;

Hehn, Joerg P. ;

Gnamm, Christian .

JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (13) :7081-7107

[70] Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor [J].

Fortanet, Jorge Garcia ;

Chen, Christine Hiu-Tung ;

Chen, Ying-Nan P. ;

Chen, Zhouliang ;

Deng, Zhan ;

Firestone, Brant ;

Fekkes, Peter ;

Fodor, Michelle ;

Fortin, Pascal D. ;

Fridrich, Cary ;

Grunenfelder, Denise ;

Ho, Samuel ;

Kang, Zhao B. ;

Karki, Rajesh ;

Kato, Mitsunori ;

Keen, Nick ;

LaBonte, Laura R. ;

Larrow, Jay ;

Lenoir, Francois ;

Liu, Gang ;

Liu, Shumei ;

Lombardo, Franco ;

Majumdar, Dyuti ;

Meyer, Matthew J. ;

Palermo, Mark ;

Perez, Lawrence ;

Pu, Minying ;

Ramsey, Timothy ;

Sellers, William R. ;

Shultz, Michael D. ;

Stams, Travis ;

Towler, Christopher ;

Wang, Ping ;

Williams, Sarah L. ;

Zhang, Ji-Hu ;

LaMarche, Matthew J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (17) :7773-7782

← 2 3 4 5 6 7 8 9 10 11 →