Unveiling Parkinson's disease through biomarker research: current insights and future prospects

被引：2
作者：
Celik, Nazli Durmaz [1 ]
Ozben, Serkan [2 ]
Ozben, Tomris [3 ]
机构：
[1] Eskisehir Osmangazi Univ, Fac Med, Dept Neurol, Eskisehir, Turkiye
[2] Univ Hlth Sci, Antalya Training & Res Hosp, Dept Neurol, Antalya, Turkiye
[3] Akdeniz Univ, Med Fac, Dept Med Biochem, Antalya, Turkiye
来源：
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | 2024年 / 61卷 / 07期
关键词：
Parkinson's disease; biomarker; diagnosis; prognosis; HUMAN CEREBROSPINAL-FLUID; SERUM URIC-ACID; ALPHA-SYNUCLEIN; OXIDIZED DJ-1; CSF; MARKERS; BRAIN; ERYTHROCYTES; PROGRESSION; EXPRESSION;
D O I：
10.1080/10408363.2024.2331471
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Parkinson's disease (PD) is a neurodegenerative condition marked by the gradual depletion of dopaminergic neurons in the substantia nigra. Despite substantial strides in comprehending potential causative mechanisms, the validation of biomarkers with unequivocal evidence for routine clinical application remains elusive. Consequently, the diagnosis heavily relies on patients' clinical assessments and medical backgrounds. The imperative need for diagnostic and prognostic biomarkers arises due to the prevailing limitations of treatments, which predominantly address symptoms without modifying the disease course. This comprehensive review aims to elucidate the existing landscape of diagnostic and prognostic biomarkers for PD, drawing insights from contemporary literature.
引用
收藏
页码：529 / 545
页数：17
相关论文
共 123 条
[1]   Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease [J].
Aamodt, Whitley W. ;
Waligorska, Teresa ;
Shen, Junchao ;
Tropea, Thomas F. ;
Siderowf, Andrew ;
Weintraub, Daniel ;
Grossman, Murray ;
Irwin, David ;
Wolk, David A. ;
Xie, Sharon X. ;
Trojanowski, John Q. ;
Shaw, Leslie M. ;
Chen-Plotkin, Alice S. .
MOVEMENT DISORDERS, 2021, 36 (12) :2945-2950
[2]   Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals [J].
Akazawa, Yoko Ogawa ;
Saito, Yoshiro ;
Hamakubo, Takao ;
Masuo, Yoshinori ;
Yoshida, Yasukazu ;
Nishio, Keiko ;
Shichiri, Mototada ;
Miyasaka, Tomohiro ;
Iwanari, Hiroko ;
Mochizuki, Yasuhiro ;
Kodama, Tatsuhiko ;
Noguchi, Noriko ;
Niki, Etsuo .
NEUROSCIENCE LETTERS, 2010, 483 (03) :201-205
[3]   Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease [J].
Ascherio, Alberto ;
LeWitt, Peter A. ;
Xu, Kui ;
Eberly, Shirley ;
Watts, Arthur ;
Matson, Wayne R. ;
Marras, Connie ;
Kieburtz, Karl ;
Rudolph, Alice ;
Bogdanov, Mikhail B. ;
Schwid, Steven R. ;
Tennis, Marsha ;
Tanner, Caroline M. ;
Beal, M. Flint ;
Lang, Anthony E. ;
Oakes, David ;
Fahn, Stanley ;
Shoulson, Ira ;
Schwarzschild, Michael A. .
ARCHIVES OF NEUROLOGY, 2009, 66 (12) :1460-1468
[4]   Insulin-Like Growth Factor 1 (IGF-1) in Parkinson's Disease: Potential as Trait-, Progression- and Prediction Marker and Confounding Factors [J].
Bernhard, Felix P. ;
Heinzel, Sebastian ;
Binder, Gerhard ;
Weber, Karin ;
Apel, Anja ;
Roeben, Benjamin ;
Deuschle, Christian ;
Maechtel, Mirjam ;
Heger, Tanja ;
Nussbaum, Susanne ;
Gasser, Thomas ;
Maetzler, Walter ;
Berg, Daniela .
PLOS ONE, 2016, 11 (03)
[5]   Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].
Bonifati, V ;
Rizzu, P ;
van Baren, MJ ;
Schaap, O ;
Breedveld, GJ ;
Krieger, E ;
Dekker, MCJ ;
Squitieri, F ;
Ibanez, P ;
Joosse, M ;
van Dongen, JW ;
Vanacore, N ;
van Swieten, JC ;
Brice, A ;
Meco, G ;
van Duijn, CM ;
Oostra, BA ;
Heutink, P .
SCIENCE, 2003, 299 (5604) :256-259
[6]   New markers in Parkinson's disease [J].
Bougea, Anastasia .
ADVANCES IN CLINICAL CHEMISTRY, VOL 96, 2020, 96 :137-178
[7]   Staging of brain pathology related to sporadic Parkinson's disease [J].
Braak, H ;
Del Tredici, K ;
Rüb, U ;
de Vos, RAI ;
Steur, ENHJ ;
Braak, E .
NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211
[8]   Dopaminergic regulation of orexin neurons [J].
Bubser, M ;
Fadel, JR ;
Jackson, LL ;
Meador-Woodruff, JH ;
Jing, DQ ;
Deutch, AY .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (11) :2993-3001
[9]   \The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients [J].
Cerri, Silvia ;
Ghezzi, Cristina ;
Sampieri, Maria ;
Siani, Francesca ;
Avenali, Micol ;
Dornini, Gianluca ;
Zangaglia, Roberta ;
Minafra, Brigida ;
Blandini, Fabio .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2018, 12
[10]   Increased Noradrenaline as an Additional Cerebrospinal Fluid Biomarker in PSP-Like Parkinsonism [J].
Cerroni, Rocco ;
Liguori, Claudio ;
Stefani, Alessandro ;
Conti, Matteo ;
Garasto, Elena ;
Pierantozzi, Mariangela ;
Mercuri, Nicola B. ;
Bernardini, Sergio ;
Fucci, Giorgio ;
Massoud, Renato .
FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
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