Unveiling the next generation of MRI contrast agents: current insights and perspectives on ferumoxytol-enhanced MRI

被引：22
作者：
Si, Guangxiang [1 ]
Du, Yue [2 ]
Tang, Peng [2 ]
Ma, Gao [3 ]
Jia, Zhaochen [1 ]
Zhou, Xiaoyue [4 ]
Mu, Dan [5 ]
Shen, Yan [2 ]
Lu, Yi [6 ]
Mao, Yu [7 ]
Chen, Chuan [1 ]
Li, Yan [1 ]
Gu, Ning [1 ,7 ]
机构：
[1] Southeast Univ, Sch Biol Sci & Med Engn, Jiangsu Key Lab Biomat & Devices, Nanjing 210009, Peoples R China
[2] Nanjing Med Univ, Sch Biomed Engn & Informat, Key Lab Bioelectromagnet Environm & Adv Med Theran, Nanjing 210029, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, Nanjing 210029, Peoples R China
[4] Siemens Healthineers Ltd, MR Collaborat, Shanghai 200126, Peoples R China
[5] Nanjing Univ, Affiliated Nanjing Drum Tower Hosp, Med Sch, Dept Radiol, Nanjing 210008, Peoples R China
[6] Capital Normal Univ, Sch Math Sci, Beijing 100048, Peoples R China
[7] Nanjing Univ, Nanjing Drum Tower Hosp, Med Sch, Inst Clin Med,Nanjing Key Lab Cardiovasc Informat, Nanjing 210093, Peoples R China
来源：
NATIONAL SCIENCE REVIEW | 2024年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ferumoxytol; contrast agent; contrast-enhanced MRI; ferumoxytol-enhanced MRI; MAGNETIC-RESONANCE ANGIOGRAPHY; IRON-OXIDE NANOPARTICLES; AORTIC-VALVE-REPLACEMENT; RENAL DYSFUNCTION; CELL TRACKING; CARDIAC MRI; STEM-CELLS; GADOLINIUM; CHILDREN; SYSTEM;
D O I：
10.1093/nsr/nwae057
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Contrast-enhanced magnetic resonance imaging (CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced MRI (FE-MRI) has significantly reshaped CE-MRI practices. Unlike MRI that is enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher MRI time efficiency and the capability for molecular imaging. As a leading superparamagnetic iron oxide contrast agent, ferumoxytol is heralded as the next generation of contrast agents. This review delineates the pivotal clinical applications and inherent technical superiority of FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging the gap between clinical demands and engineering innovations. Concurrently, we spotlight the emerging imaging themes and new technical breakthroughs. Lastly, we share our own insights on the potential trajectory of FE-MRI, shedding light on its future within the medical imaging realm. This review explores how ferumoxytol-enhanced MRI revolutionizes diagnostics with safer contrast options, offering a glimpse into advanced imaging techniques and promising new directions in medical research.
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页数：20
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