DEAD Box RNA Helicases: Biochemical Properties, Role in RNA Processing and Ribosome Biogenesis

被引：2
作者：
Hussain, Ashaq [1 ]
机构：
[1] Ctr Cellular & Mol Biol, Hyderabad, India
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2024年 / 82卷 / 02期
关键词：
DEAD box RNA Helicases; RNA processing; Ribosome biogenesis; RNA rearrangement; ESCHERICHIA-COLI DBPA; MESSENGER-RNA; CRYSTAL-STRUCTURE; STRAINS LACKING; PROTEIN; DEGRADOSOME; TRANSLATION; DEGRADATION; BINDING; SITES;
D O I：
10.1007/s12013-024-01240-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DEAD box RNA helicases are a versatile group of ATP dependent enzymes that play an essential role in cellular processes like transcription, RNA processing, ribosome biogenesis and translation. These enzymes perform structural rearrangement of complex RNA molecules and enhance the productive folding of RNA and organization of macromolecular complexes. In this review article besides providing the outline about structural organization of helicases, an in-depth discussion will be done on the biochemical properties of RNA helicases like their substrate binding, binding and hydrolysis of ATP and related conformational changes that are important for functioning of the RNA helicase enzymes. I will extensively discuss the physiological role of RNA helicases in RNA processing and ribosome biogenesis.
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收藏
页码：427 / 434
页数：8
相关论文
共 87 条
[1]   Characterization of the RNA Degradosome of Pseudoalteromonas haloplanktis: Conservation of the RNase E-RhlB Interaction in the Gammaproteobacteria [J].
Ait-Bara, Soraya ;
Carpousis, Agamemnon J. .
JOURNAL OF BACTERIOLOGY, 2010, 192 (20) :5413-5423
[2]   Complementation analysis of the cold-sensitive phenotype of the Escherichia coli csdA deletion strain [J].
Awano, Naoki ;
Xu, Chunying ;
Ke, Haiping ;
Inoue, Koichi ;
Inouye, Masayori ;
Phadtare, Sangita .
JOURNAL OF BACTERIOLOGY, 2007, 189 (16) :5808-5815
[3]   Ectopic RNase E sites promote bypass of 5′-end-dependent mRNA decay in Escherichia coli [J].
Baker, KE ;
Mackie, GA .
MOLECULAR MICROBIOLOGY, 2003, 47 (01) :75-88
[4]   Global analysis of Escherichia coli RNA degradosome function using DNA microarrays [J].
Bernstein, JA ;
Lin, PH ;
Cohen, SN ;
Lin-Chao, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2758-2763
[5]   Studies on three E-coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases [J].
Bizebard, T ;
Ferlenghi, I ;
Iost, I ;
Dreyfus, M .
BIOCHEMISTRY, 2004, 43 (24) :7857-7866
[6]   Role of GTPases in Bacterial Ribosome Assembly [J].
Britton, Robert A. .
ANNUAL REVIEW OF MICROBIOLOGY, 2009, 63 :155-176
[7]  
Carpousis AJ, 2002, BIOCHEM SOC T, V30, P150, DOI 10.1042/BST0300150
[8]   Cold Adaptation in DEAD-Box Proteins [J].
Cartier, Gwendoline ;
Lorieux, Florence ;
Allemand, Frederic ;
Dreyfus, Marc ;
Bizebard, Thierry .
BIOCHEMISTRY, 2010, 49 (12) :2636-2646
[9]   Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase [J].
Caruthers, JM ;
Johnson, ER ;
McKay, DB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13080-13085
[10]   Helicase structure and mechanism [J].
Caruthers, JM ;
McKay, DB .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (01) :123-133
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