Application of stimuli-responsive nanomedicines for the treatment of ischemic stroke

被引：6

作者：

Zhan, Yongyi ^{[1
]}

Dai, Yue ^{[1
]}

Ding, Zhejing ^{[1
]}

Lu, Mingtian ^{[1
]}

He, Zehua ^{[1
]}

Chen, Zhengwei ^{[1
]}

Liu, Yongkang ^{[1
]}

Li, Zhongliang ^{[1
]}

Cheng, Guangsen ^{[1
]}

Peng, Shaojun ^{[2
]}

Liu, Yu ^{[1
]}

机构：

[1] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Intervent Med Ctr, Cerebrovasc Dis Dept,Zhuhai Clin Med Coll, Zhuhai, Peoples R China

[2] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Inst Translat Med, Zhuhai Clin Med Coll, Zhuhai, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2024年 / 11卷

基金：

中国国家自然科学基金;

关键词：

ischemic stroke; stimuli-responsive; nanomedicine; micro-environment; drug delivery; TARGETED DELIVERY; THROMBOLYSIS; PREVENTION; MANAGEMENT; NANOPARTICLES; NANOCARRIERS; THROMBECTOMY; ASSOCIATION; STRATEGY; THERAPY;

D O I：

10.3389/fbioe.2023.1329959

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ischemic stroke (IS) refers to local brain tissue necrosis which is caused by impaired blood supply to the carotid artery or vertebrobasilar artery system. As the second leading cause of death in the world, IS has a high incidence and brings a heavy economic burden to all countries and regions because of its high disability rate. In order to effectively treat IS, a large number of drugs have been designed and developed. However, most drugs with good therapeutic effects confirmed in preclinical experiments have not been successfully applied to clinical treatment due to the low accumulation efficiency of drugs in IS areas after systematic administration. As an emerging strategy for the treatment of IS, stimuli-responsive nanomedicines have made great progress by precisely delivering drugs to the local site of IS. By response to the specific signals, stimuli-responsive nanomedicines change their particle size, shape, surface charge or structural integrity, which enables the enhanced drug delivery and controlled drug release within the IS tissue. This breakthrough approach not only enhances therapeutic efficiency but also mitigates the side effects commonly associated with thrombolytic and neuroprotective drugs. This review aims to comprehensively summarize the recent progress of stimuli-responsive nanomedicines for the treatment of IS. Furthermore, prospect is provided to look forward for the better development of this field.

引用

页数：18

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