Mycobacterium tuberculosis Resides in Macrophages in Laryngeal Tuberculosis: A Case Report

被引：0

作者：

Achache, Wafaa ^{[1
,2
]}

Boualam, Mahmoud A. ^{[1
,2
]}

Cassir, Nadim ^{[1
,2
]}

Mimari, Clemence ^{[3
]}

Poitrenaud, Delphine ^{[4
]}

Mezouar, Soraya ^{[1
,2
]}

Mege, Jean Louis ^{[1
,2
]}

Drancourt, Michel ^{[1
]}

Lepidi, Hubert ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, MEPHI, IRD, F-13005 Marseille, France

[2] IHU Mediterranee Infect, F-13005 Marseille, France

[3] Hop Conception, Serv ORL, F-13005 Marseille, France

[4] CH Ajaccio, Serv Malad Infectieuses, F-20000 Ajaccio, France

来源：

PATHOGENS | 2023年 / 12卷 / 12期

关键词：

larynx; tuberculosis; granuloma; Mycobacterium tuberculosis; laryngitis; extrapulmonary tuberculosis;

D O I：

10.3390/pathogens12121413

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis that questions the natural history of this infection. We report one such case in which a pathological examination of a laryngeal biopsy revealed granulomatous inflammation with caseous necrosis. Further investigations combining immunofluorescence detection of macrophages and in situ hybridization of Mycobacterium tuberculosis indicated the presence of Mycobacterium tuberculosis (M. tuberculosis) in laryngeal granulomatous inflammatory lesions. This observation suggests that the natural history of laryngeal tuberculosis does not differ from that of other forms, guiding early diagnosis in patients with laryngeal lesions to ensure appropriate check-ups and treatment.

引用

页数：6

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