Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires anti-inflammatory drugs, analgesics, and tissue protectors. To deal with this disease, the pain and inflammation should be relieved in the first stage, and tissue protectors should be used to restore joint damage that limits movement. Therefore, a comprehensive multifunctional core-shell nanocomposite (TFH@ TA/AuNPs-HDA) with a continuous anti-inflammatory effect and a special tissue protection potential in the core was designed. Here, the hydrothermal reaction was applied to synthesize the hydrogel core from tragacanth and frankincense gums; then, the shell was self-assembled with tannic acid/gold nanoparticles (TA/AuNPs) and 10-hydroxy-2-decanoic acid (10-HDA). The biocompatibility, anti-inflammatory properties, and tissue protective effect of TFH@ TA/AuNPs-HDA were investigated on RAW264.7 cells and in collagen-induced RA rat models. Moreover, the molecular docking demonstrated the interactions of 10-HDA and AuNPs with NF -KB signaling pathway proteins, confirming the anti-inflammatory effect of 10-HDA and AuNP suppression of the NF -KB pathway. The results revealed that TFH@TA/AuNPs-HDA could be an appropriate system for RA therapy due to the synergistic alleviation of inflammation and joint tissue destruction.
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Univ Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, OmanUniv Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
Al-Harrasi, Ahmed
Csuk, Rene
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Martin Luther Univ Halle Wittenberg, Organ Chem, Kurt Mothes Str 2, D-06120 Halle, Saale, GermanyUniv Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
Csuk, Rene
Khan, Ajmal
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Univ Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, OmanUniv Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
机构:
Indian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
Indian Inst Technol Kharagpur, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, IndiaIndian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
Apoorva, Anupam
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Rameshbabu, Arun Prabhu
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Dasgupta, Swagata
Dhara, Santanu
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Indian Inst Technol Kharagpur, Dept Chem, Khamgpur 721302, IndiaIndian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
Dhara, Santanu
Padmavati, Manchikanti
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Indian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, IndiaIndian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
机构:
China Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 40402, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Cheng, Hui-Man
Kuo, Yi-Zih
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Natl Cheng Kung Univ, Coll Med, Dept Otolaryngol, Tainan 70428, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Kuo, Yi-Zih
Chang, Che-Ying
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Natl Cheng Kung Univ, Coll Med, Inst Mol Med, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Chang, Che-Ying
Chang, Chun-Han
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Natl Cheng Kung Univ, Coll Med, Inst Mol Med, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Chang, Chun-Han
Fang, Wei-Yu
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Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Fang, Wei-Yu
Chang, Chen-Ni
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Natl Cheng Kung Univ, Coll Med, Inst Mol Med, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Chang, Chen-Ni
Pan, Shin-Chen
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Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg,Sect Plast & Reconstruct Surg, 138 Sheng Li Rd, Tainan 70428, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
机构:
Univ Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, OmanUniv Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
Al-Harrasi, Ahmed
Csuk, Rene
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h-index: 0
机构:
Martin Luther Univ Halle Wittenberg, Organ Chem, Kurt Mothes Str 2, D-06120 Halle, Saale, GermanyUniv Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
Csuk, Rene
Khan, Ajmal
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h-index: 0
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Univ Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, OmanUniv Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
机构:
Indian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
Indian Inst Technol Kharagpur, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, IndiaIndian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
Apoorva, Anupam
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Rameshbabu, Arun Prabhu
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机构:
Dasgupta, Swagata
Dhara, Santanu
论文数: 0引用数: 0
h-index: 0
机构:
Indian Inst Technol Kharagpur, Dept Chem, Khamgpur 721302, IndiaIndian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
Dhara, Santanu
Padmavati, Manchikanti
论文数: 0引用数: 0
h-index: 0
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Indian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, IndiaIndian Inst Technol Kharagpur, Sch Biosci, Kharagpur 721302, W Bengal, India
机构:
China Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 40402, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Cheng, Hui-Man
Kuo, Yi-Zih
论文数: 0引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Coll Med, Dept Otolaryngol, Tainan 70428, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Kuo, Yi-Zih
Chang, Che-Ying
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h-index: 0
机构:
Natl Cheng Kung Univ, Coll Med, Inst Mol Med, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Chang, Che-Ying
Chang, Chun-Han
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h-index: 0
机构:
Natl Cheng Kung Univ, Coll Med, Inst Mol Med, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Chang, Chun-Han
Fang, Wei-Yu
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h-index: 0
机构:
Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Fang, Wei-Yu
Chang, Chen-Ni
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h-index: 0
机构:
Natl Cheng Kung Univ, Coll Med, Inst Mol Med, 1 Univ Rd, Tainan 70101, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan
Chang, Chen-Ni
Pan, Shin-Chen
论文数: 0引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg,Sect Plast & Reconstruct Surg, 138 Sheng Li Rd, Tainan 70428, TaiwanChina Med Univ Hosp, Dept Integrat Tradit Chinese & Western Med, 2 Yuh Der Rd, Taichung 40447, Taiwan