Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB

被引：177

作者：

Imai, Masaki ^{[1
]}

Ito, Mutsumi ^{[1
]}

Kiso, Maki ^{[1
]}

Yamayoshi, Seiya ^{[1
]}

Uraki, Ryuta ^{[1
]}

Fukushi, Shuetsu ^{[2
]}

Watanabe, Shinji ^{[2
]}

Suzuki, Tadaki ^{[2
]}

Maeda, Ken ^{[2
]}

Sakai-Tagawa, Yuko ^{[1
]}

Iwatsuki-Horimoto, Kiyoko ^{[1
]}

Halfmann, Peter J. ^{[3
]}

Kawaoka, Yoshihiro ^{[1
]}

机构：

[1] Univ Tokyo, Tokyo, Japan

[2] Natl Inst Infect Dis, Tokyo, Japan

[3] Univ Wisconsin Madison, Madison, WI USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2023年 / 388卷 / 01期

关键词：

D O I：

10.1056/NEJMc2214302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiviral Agents and Omicron BQ.1.1 and XBB Neither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and nirmatrelvir were efficacious against both in vitro.

引用

页码：89 / 91

页数：3

共 5 条

[1] BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Cao, Yunlong
Yisimayi, Ayijiang
Jian, Fanchong
Song, Weiliang
Xiao, Tianhe
Wang, Lei
Du, Shuo
Wang, Jing
Li, Qianqian
Chen, Xiaosu
Yu, Yuanling
Wang, Peng
Zhang, Zhiying
Liu, Pulan
An, Ran
Hao, Xiaohua
Wang, Yao
Feng, Rui
Sun, Haiyan
Zhao, Lijuan
Zhang, Wen
Zhao, Dong
Zheng, Jiang
Yu, Lingling
Li, Can
Zhang, Na
Wang, Rui
Niu, Xiao
Yang, Sijie
Song, Xuetao
Chai, Yangyang
Hu, Ye
Shi, Yansong
Zheng, Linlin
Li, Zhiqiang
Gu, Qingqing
Shao, Fei
Huang, Weijin
Jin, Ronghua
Shen, Zhongyang
Wang, Youchun
Wang, Xiangxi
Xiao, Junyu
Xie, Xiaoliang Sunney
[J]. NATURE, 2022, 608 (7923) : 593 - +
[2] Iketani S, 2022, NATURE, V604, P553, DOI 10.1038/s41586-022-04594-4
[3] Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants
Takashita, Emi
Yamayoshi, Seiya
Simon, Viviana
Van Bakel, Harm
Sordillo, Emilia M.
Pekosz, Andrew
Fukushi, Shuetsu
Suzuki, Tadaki
Maeda, Ken
Halfmann, Peter
Sakai-Tagawa, Yuko
Ito, Mutsumi
Watanabe, Shinji
Imai, Masaki
Hasegawa, Hideki
Kawaoka, Yoshihiro
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (05) : 468 - 470
[4] Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2
Takashita, Emi
Kinoshita, Noriko
Yamayoshi, Seiya
Sakai-Tagawa, Yuko
Fujisaki, Seiichiro
Ito, Mutsumi
Iwatsuki-Horimoto, Kiyoko
Halfmann, Peter
Watanabe, Shinji
Maeda, Kenji
Imai, Masaki
Mitsuya, Hiroaki
Ohmagari, Norio
Takeda, Makoto
Hasegawa, Hideki
Kawaoka, Yoshihiro
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (15) : 1475 - 1477
[5] Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5
Wang, Qian
Guo, Yicheng
Iketani, Sho
Nair, Manoj S.
Li, Zhiteng
Mohri, Hiroshi
Wang, Maple
Yu, Jian
Bowen, Anthony D.
Chang, Jennifer Y.
Shah, Jayesh G.
Nguyen, Nadia
Chen, Zhiwei
Meyers, Kathrine
Yin, Michael T.
Sobieszczyk, Magdalena E.
Sheng, Zizhang
Huang, Yaoxing
Liu, Lihong
Ho, David D.
[J]. NATURE, 2022, 608 (7923) : 603 - +

← 1 →