The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain

被引:8
作者
Chu, Yanhao [1 ,2 ]
He, Hongwen [2 ]
Liu, Qing [1 ,2 ]
Jia, Shilin [1 ,2 ]
Fan, Wenguo [2 ]
Huang, Fang [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangzhou, Peoples R China
[2] Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Circadian clocks; Molecular clocks; Diurnal oscillations; Pain; Circadian pain; NITRIC-OXIDE SYNTHASE; MESSENGER-RNA EXPRESSION; N-TERMINAL KINASE; SUBSTANCE-P; SUPRACHIASMATIC NUCLEUS; GENE-EXPRESSION; GLUTAMATE RECEPTORS; DIURNAL PREFERENCE; NEUROPATHIC PAIN; PINEAL-GLAND;
D O I
10.1007/s10571-022-01205-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The circadian clock is a biochemical oscillator that is synchronized with solar time. Normal circadian rhythms are necessary for many physiological functions. Circadian rhythms have also been linked with many physiological functions, several clinical symptoms, and diseases. Accumulating evidence suggests that the circadian clock appears to modulate the processing of nociceptive information. Many pain conditions display a circadian fluctuation pattern clinically. Thus, the aim of this review is to summarize the existing knowledge about the circadian clocks involved in diurnal rhythms of pain. Possible cellular and molecular mechanisms regarding the connection between the circadian clocks and pain are discussed.
引用
收藏
页码:511 / 523
页数:13
相关论文
共 142 条
[91]   Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice [J].
Morioka, Norimitsu ;
Saeki, Munenori ;
Sugimoto, Tatsuhiko ;
Higuchi, Takuya ;
Zhang, Fang Fang ;
Nakamura, Yoki ;
Hisaoka-Nakashima, Kazue ;
Nakata, Yoshihiro .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2016, 72 :72-83
[92]   The induction of Pen1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes [J].
Morioka, Norimitsu ;
Sugimoto, Tatsuhiko ;
Sato, Koichi ;
Okazaki, Shuji ;
Saeki, Munenori ;
Hisaoka-Nakashima, Kazue ;
Nakata, Yoshihiro .
NEUROCHEMISTRY INTERNATIONAL, 2015, 90 :9-19
[93]   Activation of central terminal vanilloid receptor-1 receptors and αβ-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord [J].
Nakatsuka, T ;
Furue, H ;
Yoshimura, M ;
Gu, JGG .
JOURNAL OF NEUROSCIENCE, 2002, 22 (04) :1228-1237
[94]   CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch [J].
Narasimamurthy, Rajesh ;
Hunt, Sabrina R. ;
Lu, Yining ;
Fustin, Jean-Michel ;
Okamura, Hitoshi ;
Partch, Carrie L. ;
Forger, Daniel B. ;
Kim, Jae Kyoung ;
Virshup, David M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (23) :5986-5991
[95]   Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease [J].
Olson, Nels ;
van der Vliet, Albert .
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2011, 25 (02) :125-137
[96]   The circadian clock at the intercept of sleep and pain [J].
Palada, Vinko ;
Gilron, Ian ;
Canlon, Barbara ;
Svensson, Camilla, I ;
Kalso, Eija .
PAIN, 2020, 161 (05) :894-900
[97]   Coordinated transcription of key pathways in the mouse by the circadian clock [J].
Panda, S ;
Antoch, MP ;
Miller, BH ;
Su, AI ;
Schook, AB ;
Straume, M ;
Schultz, PG ;
Kay, SA ;
Takahashi, JS ;
Hogenesch, JB .
CELL, 2002, 109 (03) :307-320
[98]   Nitric Oxide: Perspectives and Emerging Studies of a Well Known Cytotoxin [J].
Paradise, William A. ;
Vesper, Benjamin J. ;
Goel, Ajay ;
Waltonen, Joshua D. ;
Altman, Kenneth W. ;
Haines, G. Kenneth, III ;
Radosevich, James A. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (07) :2715-2745
[99]   Molecular architecture of the mammalian circadian clock [J].
Partch, Carrie L. ;
Green, Carla B. ;
Takahashi, Joseph S. .
TRENDS IN CELL BIOLOGY, 2014, 24 (02) :90-99
[100]   Astrocytic purinergic signaling coordinates synaptic networks [J].
Pascual, O ;
Casper, KB ;
Kubera, C ;
Zhang, J ;
Revilla-Sanchez, R ;
Sul, JY ;
Takano, H ;
Moss, SJ ;
McCarthy, K ;
Haydon, PG .
SCIENCE, 2005, 310 (5745) :113-116