Construction of Smart DNA-Based Drug Delivery Systems for Cancer Therapy

被引:8
|
作者
Li, Congcong [1 ]
Wang, Mengzhen [1 ]
Li, Pei-Feng [1 ]
Sheng, Junyue [2 ]
Fu, Qinrui [1 ]
机构
[1] Qingdao Univ, Affiliated Hosp, Inst Translat Med, Coll Med, Qingdao 266021, Peoples R China
[2] Qingdao 58 High Sch Shandong Prov, 20 Jiushui Rd, Qingdao 266100, Peoples R China
关键词
controlled drug release; DNA nanomaterial; enhanced biological stability; smart-responsive drug delivery system; targeted drug delivery; INTRACELLULAR DELIVERY; TARGETED DELIVERY; NANOSTRUCTURES; ATP; APTAMER; ORIGAMI; TETRAHEDRON; PLATFORM; CELLS; NANOPARTICLES;
D O I
10.1002/smll.202306257
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Due to the disadvantages of poor targeting, slow action, and low effectiveness of current commonly used cancer treatments, including surgery, chemotherapy, and radiotherapy, researchers have turned to DNA as a biomaterial for constructing drug delivery nanocarriers. DNA is favored for its biocompatibility and programmability. In order to overcome the limitations associated with traditional drug delivery systems (DDSs), researchers have developed smart-responsive DNA DDSs that can control drug release in response to specific physical or chemical stimuli at targeted sites. In this review, a summary of multiple targeted ligand structures is provided, various shapes of stable DNA nanomaterials, and different stimuli-responsive drug release strategies in DNA DDSs. Specifically, targeted cell recognition, in vivo stable transport, and controlled drug release of smart DDSs are focused. Finally, the further development prospects and challenges of clinical application of DNA nanomaterials in the field of smart drug delivery are discussed. The objective of this review is to enhance researchers' comprehension regarding the potential application of DNA nanomaterials in precision drug delivery, with the aim of expediting the clinical implementation of intelligent DDSs. The review introduces design methods of smart DNA-based drug delivery system from three aspects: targeted recognition, in vivo stable transport, and controlled drug release. This review can help researchers to understand DNA nanomaterials and their application potential in drug delivery, and further promote the clinical application of smart DDSs. image
引用
收藏
页数:20
相关论文
共 50 条
  • [21] Smart Drug Delivery Strategies for Cancer Therapy
    Mendoza, Carlos Miguel Lopez
    Quintana, Luz Eugenia Alcantara
    FRONTIERS IN NANOTECHNOLOGY, 2022, 3
  • [22] Nucleic acid drugs and DNA-based delivery systems
    Nishikawa, Makiya
    DRUG DISCOVERIES AND THERAPEUTICS, 2016, 10 (05): : 271 - +
  • [23] Recent advances in "smart" delivery systems for extended drug release in cancer therapy
    Kalaydina, Regina-Veronicka
    Bajwa, Komal
    Qorri, Bessi
    Decarlo, Alexandria
    Szewczuk, Myron R.
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 : 4727 - 4745
  • [24] Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review
    Khan, Md Ishak
    Hossain, M. Imran
    Hossain, M. Khalid
    Rubel, M. H. K.
    Hossain, K. M.
    Mahfuz, A. M. U. B.
    Anik, Muzahidul, I
    ACS APPLIED BIO MATERIALS, 2022, 5 (03) : 971 - 1012
  • [25] A DNA-based nanocarrier for efficient cancer therapy
    Abbas, Muhammad
    Baig, Mirza Muhammad Faran Ashraf
    Zhang, Yaliang
    Yang, Yu-Shun
    Wu, Songyu
    Hu, Yiqiao
    Wang, Zhong-Chang
    Zhu, Hai-Liang
    JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 11 (03) : 330 - 339
  • [26] Review on design strategies and considerations of polysaccharide-based smart drug delivery systems for cancer therapy
    Meng, Qingye
    Zhong, Shuangling
    Xu, Lifeng
    Wang, Jingfei
    Zhang, Zhenqian
    Gao, Yan
    Cui, Xuejun
    CARBOHYDRATE POLYMERS, 2022, 279
  • [27] A DNA-based nanocarrier for efficient cancer therapy
    Muhammad Abbas
    Mirza Muhammad Faran Ashraf Baig
    Yaliang Zhang
    Yu-Shun Yang
    Songyu Wu
    Yiqiao Hu
    Zhong-Chang Wang
    Hai-Liang Zhu
    Journal of Pharmaceutical Analysis, 2021, 11 (03) : 330 - 339
  • [28] A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery
    Jiang, Kai
    Chen, Yunsheng
    Zhao, Di
    Cheng, Jin
    Mo, Fangli
    Ji, Bin
    Gao, Chao
    Zhang, Chuan
    Song, Jie
    NANOSCALE, 2020, 12 (36) : 18682 - 18691
  • [29] In vivo DNA-based therapy in the treatment of cancer
    Hersh, EM
    Gutheil, J
    Gillespie, D
    CANCER GENE THERAPY, 2000, 7 (12) : S23 - S23
  • [30] DNA response element-based smart drug delivery systems for precise drug release
    Xuan, Jinnan
    Wang, Zhen
    Huang, Yuting
    Liu, Yisi
    Han, Yuqiang
    Li, Man
    Xiao, Mingshu
    BIOMATERIALS SCIENCE, 2024, 12 (14) : 3550 - 3564