Lenvatinib Suppresses Protein Kinase B Signaling and Induces Apoptosis in Osteosarcoma Cells

被引：3

作者：

Li, Chun-Yi ^{[1
]}

Chen, Hsin-Chuan ^{[1
,2
]}

Liao, Chih-Ying ^{[3
]}

Hsu, Fei-Ting ^{[4
]}

Hung, Kuang-Chen ^{[5
,6
,7
,8
,9
]}

Liu, Kuo-Ching ^{[1
,10
]}

Chen, Jaw-Chyun ^{[1
,11
]}

Ku, Ming-Chou ^{[1
,2
,12
,13
]}

机构：

[1] Show Chwan Mem Hosp, Dept Orthoped, Changhua, Taiwan

[2] Chung Shan Med Univ, Inst Stomatol, Taichung, Taiwan

[3] Chang Bing Show Chwan Mem Hosp, Dept Radiat Oncol, Changhua, Taiwan

[4] China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan

[5] Zuoying Armed Forces Gen Hosp, Dept Surg, Kaohsiung, Taiwan

[6] Natl Def Med Ctr, Dept Surg, Taipei, Taiwan

[7] Taichung Armed Forces Gen Hosp, Dept Surg, Taichung, Taiwan

[8] Cent Taiwan Univ Sci & Technol, Taichung, Taiwan

[9] Natl Chin Yi Univ Technol, Taichung, Taiwan

[10] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan

[11] Da Yeh Univ, Dept Med Bot & Foods Hlth Applicat, Changhua, Taiwan

[12] Cent Taiwan Univ Sci & Technol, Dept Med Imaging & Radiol Sci, Taichung, Taiwan

[13] Show Chwan Mem Hosp, Dept Neurosurg, 542 Sec 1,Chung Shang Rd, Changhua 505, Taiwan

来源：

ANTICANCER RESEARCH | 2024年 / 44卷 / 01期

关键词：

Lenvatinib; osteosarcoma; AKT; apoptosis; invasion; CYCLIN D1; SORAFENIB; INHIBITION; ACTIVATION; EXPRESSION; PATHWAYS; GROWTH; MMP-9;

D O I：

10.21873/anticanres.16790

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Lenvatinib, an oral multikinase inhibitor, has demonstrated promising activity in patients with osteosarcoma (OS). Therefore, it is worth exploring the inhibitory efficacy and mechanism of action of lenvatinib in osteosarcoma. The primary goal of this study was to examine the inhibitory effectiveness and mechanism of lenvatinib on the growth and invasion of OS cells. Materials and Methods: The effects of lenvatinib on cell viability, apoptosis, protein involved in tumor progression, and invasion capability were assessed using MTT assay, flow cytometry, western blotting, and invasion/migration assay on U-2 OS and MG63 cells. apoptosis, as well as extrinsic and intrinsic apoptotic signaling in OS cells. Lenvatinib also significantly decreased the invasion/migration capability, AKT activation, and

引用

页码：85 / 92

页数：8

共 35 条

[21] Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines [J].