Thiazolidin-4-Ones as a Promising Scaffold in the Development of Antibiofilm Agents-A Review

被引：3
|
作者：
Trotsko, Nazar [1 ]
机构：
[1] Med Univ Lublin, Fac Pharm, Dept Organ Chem, 4A Chodzki St, PL-20093 Lublin, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 01期
关键词：
thiazolidin-4-one; rhodamine; thiazolidine-2,4-dione; biofilm; antibiofilm activity; HISTIDINE KINASE YYCG; ANTIBACTERIAL ACTIVITY; BACTERIAL BIOFILM; SUSTAINED-RELEASE; RNA-POLYMERASE; DERIVATIVES; DESIGN; THIAZOLIDINE-2,4-DIONE; THIAZOLIDINEDIONE; INHIBITORS;
D O I：
10.3390/ijms25010325
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thiazolidin-4-ones have a broad range of medical and clinical implementation, which is important for pharmaceutical and medicinal chemistry. This heterocyclic core has been reported to possess a diversity of bioactivities, including antimicrobial and antibiofilm-forming potential. The resistance of biofilms to antibiotics or disinfectants is a serious medical problem. Therefore, there is a natural need to discover new effective structures with properties that inhibit biofilm formation. This review aims to analyze the antibiofilm features of thiazolidin-4-ones described in the literature over the last two decades. The information gathered in this review could benefit the rational design of new effective antibiofilm small molecules with thiazolidin-4-one cores.
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页数：22
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