t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report

被引：1

作者：

El Mahdaoui, Chaimae ^{[1
]}

Hda, Nezha ^{[2
]}

Oukkache, Bouchra ^{[3
]}

Dehbi, Hind ^{[1
,4
,5
]}

Khoubila, Nisrine ^{[5
]}

Madani, Abdellah ^{[5
]}

Cherkaoui, Siham ^{[1
,5
]}

机构：

[1] Hassan II Univ Casablanca, Fac Med & Pharm, Lab Cellular & Mol Pathol, Casablanca, Morocco

[2] Hda Labs Med Biol Anal, Casablanca, Morocco

[3] Ibn Rochd Univ Hosp, Hematol Lab, Casablanca, Morocco

[4] Ibn Rochd Univ Hosp, Lab Med Genet, Casablanca, Morocco

[5] Ibn Rochd Univ Hosp, Hematol & Pediat Oncol Dept August 20 Hosp, Casablanca, Morocco

来源：

JOURNAL OF MEDICAL CASE REPORTS | 2023年 / 17卷 / 01期

关键词：

Acute lymphoblastic leukemia; Cytogenetics; B-ALL; Case report; ONCOLOGY;

D O I：

10.1186/s13256-023-04270-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundAcute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome and prognosis of acute lymphoblastic leukemia in children depends on various factors, such as age, clinical and biological features, and cytogenetic factors.Case presentationWe report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality.ConclusionTranslocation (1;4)(p21;p15) is a relatively rare chromosomal abnormality found in human leukemia and was never described isolated in pediatric B-cell acute lymphoblastic leukemia patients. It showed a good evolution by complete remission and recovery of this patient after receiving all chemotherapy and after 8 years of follow-up.

引用

页数：5

共 18 条

[1] Rare Cytogenetic Anomalies in Two Pediatric Patients with Acute Leukemia [J].

Bozkurt, Sureyya ;

Unal, Sule ;

Bayhan, Turan ;

Gumruk, Fatma ;

Cetin, Mualla .

TURKISH JOURNAL OF HEMATOLOGY, 2020, 37 (02) :132-133

[2] MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)-Current Treatment Options. Is There a Role for CAR-T Cell Therapy? [J].

Britten, Oliver ;

Ragusa, Denise ;

Tosi, Sabrina ;

Kamel, Yasser Mostafa .

CELLS, 2019, 8 (11)

[3] A constitutional translocation t(1;4)(p21;p15) in a case of chronic lymphocytic leukemia [J].

Eclache, V ;

Benzacken, B ;

Kettaneh, A ;

Fain, O .

ANNALES DE GENETIQUE, 2002, 45 (04) :169-171

[4] Acute Lymphoblastic Leukemia in Children [J].

Hunger, Stephen P. ;

Mullighan, Charles G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (16) :1541-1552

[5] Atlas of genetics and cytogenetics in oncology and haematology, updated [J].

Huret, JL ;

Dessen, P ;

Bernheim, A .

NUCLEIC ACIDS RESEARCH, 2001, 29 (01) :303-304

[6] Treatment and biology of pediatric acute lymphoblastic leukemia [J].

Kato, Motohiro ;

Manabe, Atsushi .

PEDIATRICS INTERNATIONAL, 2018, 60 (01) :4-12

[7]

Nakase K, 1996, AM J CLIN PATHOL, V105, P761

[8]

National Cancer Institute, 2023, Mitelman Database of Chromosome Aberrations in Cancer

[9] Karyotyping, FISH, and PCR in Acute Lymphoblastic Leukemia Competing or Complementary Diagnostics? [J].

Nordkamp, Louise Olde ;

Mellink, Clemens ;

van der Schoot, Ellen ;

van den Berg, Henk .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2009, 31 (12) :930-935

[10] Immunophenotypic dissection of normal hematopoiesis [J].

Orfao, Alberto ;

Matarraz, Sergio ;

Perez-Andres, Martin ;

Almeida, Julia ;

Teodosio, Cristina ;

Berkowska, Magdalena A. ;

van Dongen, Jacques J. M. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2019, 475

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