HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature

被引：4
作者：
Liao, Jin-Mao [1 ]
Zhan, Yan [2 ,3 ,4 ,5 ]
Zhang, Zheng [1 ]
Cui, Jia-Jia [2 ,3 ,4 ,5 ,6 ]
Yin, Ji-Ye [2 ,3 ,4 ,5 ]
机构：
[1] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Hepotol, Changsha, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha, Peoples R China
[3] Cent South Univ, Inst Clin Pharmacol, Changsha, Peoples R China
[4] Cent South Univ, Minist Educ, Engn Res Ctr Appl Technol Pharmacogen, Changsha, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[6] Cent South Univ, Xiangya Hosp, Dept Geriatr Surg, Changsha, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
IM-ADRs; DILI; HLA polymorphism; genetic susceptibility; liver injury; STEVENS-JOHNSON SYNDROME; ADVERSE DRUG-REACTIONS; HLA-B-ASTERISK-1502; ALLELE; HEPATITIS; ASSOCIATION; HAN; CARBAMAZEPINE; METABOLISM; HAPLOTYPES; GENETICS;
D O I：
10.3389/fphar.2023.1288068
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Drug-induced liver injury (DILI) is one of the serious adverse drug reactions (ADRs), which belongs to immune-mediated adverse drug reactions (IM-ADRs). As an essential health drug, albendazole has rarely been reported to cause serious liver damage. A young man in his 30 s developed severe jaundice, abnormal transaminases, and poor blood coagulation mechanism after taking albendazole, and eventually developed into severe liver failure. The patient was found heterozygous of HLA-B*15:02 and HLA-B*13:01 through HLA-targeted sequencing, which may have a pathogenic role in the disease. This case report summarizes his presentation, treatment, and prognosis. A useful summary of the diagnosis and associated genetic variant information is provided.
引用
收藏
页数：7
相关论文
共 45 条
  • [11] HLA-B☆5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
    Daly, Ann K.
    Donaldson, Peter T.
    Bhatnagar, Pallav
    Shen, Yufeng
    Pe'er, Itsik
    Floratos, Aris
    Daly, Mark J.
    Goldstein, David B.
    John, Sally
    Nelson, Matthew R.
    Graham, Julia
    Park, B. Kevin
    Dillon, John F.
    Bernal, William
    Cordell, Heather J.
    Pirmohamed, Munir
    Aithal, Guruprasad P.
    Day, Christopher P.
    [J]. NATURE GENETICS, 2009, 41 (07) : 816 - U71
  • [12] Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1
    de Boer, Ynto S.
    van Gerven, Nicole M. F.
    Zwiers, Antonie
    Verwer, Bart J.
    van Hoek, Bart
    van Erpecum, Karel J.
    Beuers, Ulrich
    van Buuren, Henk R.
    Drenth, Joost P. H.
    den Ouden, Jannie W.
    Verdonk, Robert C.
    Koek, Ger H.
    Brouwer, Johannes T.
    Guichelaar, Maureen M. J.
    Vrolijk, Jan M.
    Kraal, Georg
    Mulder, Chris J. J.
    van Nieuwkerk, Carin M. J.
    Fischer, Janett
    Berg, Thomas
    Stickel, Felix
    Sarrazin, Christoph
    Schramm, Christoph
    Lohse, Ansgar W.
    Weiler-Normann, Christina
    Lerch, Markus M.
    Nauck, Matthias
    Voelzke, Henry
    Homuth, Georg
    Bloemena, Elisabeth
    Verspaget, Hein W.
    Kumar, Vinod
    Zhernakova, Alexandra
    Wijmenga, Cisca
    Franke, Lude
    Bouma, Gerd
    [J]. GASTROENTEROLOGY, 2014, 147 (02) : 443 - +
  • [13] Immunopharmacogenomics: Mechanisms of HLA-Associated Drug Reactions
    Deshpande, Pooja
    Hertzman, Rebecca J.
    Palubinsky, Amy M.
    Giles, Jason B.
    Karnes, Jason H.
    Gibson, Andrew
    Phillips, Elizabeth J.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 110 (03) : 607 - 615
  • [14] Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis
    Eid, Rania K.
    Ashour, Dalia S.
    Essa, Ebtessam A.
    El Maghraby, Gamal M.
    Arafa, Mona F.
    [J]. CARBOHYDRATE POLYMERS, 2020, 232
  • [15] Pharmacogenomics of off-target adverse drug reactions
    Garon, Sarah L.
    Pavlos, Rebecca K.
    White, Katie D.
    Brown, Nancy J.
    Stone, Cosby A., Jr.
    Phillips, Elizabeth J.
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2017, 83 (09) : 1896 - 1911
  • [16] Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions
    Gibson, Andrew
    Deshpande, Pooja
    Campbell, Chelsea N.
    Krantz, Matthew S.
    Mukherjee, Eric
    Mockenhaupt, Maja
    Pirmohamed, Munir
    Palubinsky, Amy M.
    Phillips, Elizabeth J.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : 289 - +
  • [17] THE METABOLISM OF BENZIMIDAZOLE ANTHELMINTICS
    GOTTSCHALL, DW
    THEODORIDES, VJ
    WANG, R
    [J]. PARASITOLOGY TODAY, 1990, 6 (04): : 115 - &
  • [18] Albendazole-induced toxic hepatitis: A case report
    Gozukucuk, Ramazan
    Abci, Ilker
    Guclu, Mustafa
    [J]. TURKISH JOURNAL OF GASTROENTEROLOGY, 2013, 24 (01) : 82 - 84
  • [19] Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    Hetherington, S
    Hughes, AR
    Mosteller, M
    Shortino, D
    Baker, KL
    Spreen, W
    Lai, E
    Davies, K
    Handley, A
    Dow, DJ
    Fling, ME
    Stocum, M
    Bowman, C
    Thurmond, LM
    Roses, AD
    [J]. LANCET, 2002, 359 (9312) : 1121 - 1122
  • [20] Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
    Kang, Hye-Ryun
    Jee, Young Koo
    Kim, Yon-Soo
    Lee, Chang Hwa
    Jung, Jae-Woo
    Kim, Sae Hoon
    Park, Heung-Woo
    Chang, Yoon-Seok
    Jang, In-Jin
    Cho, Sang-Heon
    Min, Kyung-Up
    Kim, Sang-Heon
    Lee, Kyung Wha
    [J]. PHARMACOGENETICS AND GENOMICS, 2011, 21 (05) : 303 - 307
12345