Beta-cyclodextrin - Citric acid complexation by ball milling and annealing

被引：4
|
作者：
Sarafska, Tsveta [1 ]
Ivanova, Stanislava [1 ]
Dudev, Todor [1 ]
Petrov, Vesselin [1 ]
Spassov, Tony [1 ]
机构：
[1] Sofia Univ St Kl Ohridski, Fac Chem & Pharm, Sofia 1164, Bulgaria
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2024年 / 1295卷
关键词：
Cyclodextrin; Citric acid; Complex; Binding mechanism; DEEP EUTECTIC SOLVENTS; IONIC LIQUIDS; HIGHLY EFFICIENT; ALCOHOLS; CAVITY;
D O I：
10.1016/j.molstruc.2023.136701
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In the present study Beta-cyclodextrin (beta-CD) and Citric acid (CA) molecules were shown to interact by both ball milling (BM) and annealing treatments. Thermal and structural properties of the resulting complexes formed at different conditions were characterized. Applying theoretical modeling (quantum calculations) the beta-CD/CA interaction was confirmed and the binding sides were determined. During ball milling at room temperature citric acid was found to be located inside the beta-CD cavity, accompanied by partial cyclodextrin dehydration. The results obtained provide an answer to the question what the binding mechanism of the beta-CD/CA molecules is, having a determining bearing on the potential application of the formed complexes.
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页数：7
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