MicroRNA targeting: A novel therapeutic intervention for ovarian cancer

被引：9

作者：

Asl, Elmira Roshani ^{[1
]}

Sarabandi, Sajed ^{[2
]}

Shademan, Behrouz ^{[3
]}

Dalvandi, Kourosh ^{[4
]}

Sheikhansari, Golshan ^{[5
]}

Nourazarian, Alireza ^{[6
]}

机构：

[1] Saveh Univ Med Sci, Social Determinants Hlth Res Ctr, Saveh, Iran

[2] Islamic Azad Univ Karaj, Fac Med Sci, Dept Vet, Karaj, Iran

[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[4] Minist Hlth & Med Educ, Hlth Dept, Tehran, Iran

[5] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[6] Khoy Univ Med Sci, Dept Basic Med Sci, Khoy, Iran

来源：

BIOCHEMISTRY AND BIOPHYSICS REPORTS | 2023年 / 35卷

关键词：

Ovarian cancer; microRNA; Prognostics; Biomarker; Diagnostic biomarker; Therapeutic strategy; MESSENGER-RNAS; BREAST-CANCER; HEPATITIS-C; EXPRESSION; BIOMARKER; FAMILY; PROGRESSION; MECHANISMS; DIAGNOSIS; SEQUENCE;

D O I：

10.1016/j.bbrep.2023.101519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ovarian cancer, a perilous form of cancer affecting the female reproductive system, exhibits intricate communication networks that contribute to its progression. This study aims to identify crucial molecular abnormalities linked to the disease to enhance diagnostic and therapeutic strategies. In particular, we investigate the role of microRNAs (miRNAs) as diagnostic biomarkers and explore their potential in treating ovarian cancer. By targeting miRNAs, which can influence multiple pathways and genes, substantial therapeutic benefits can be attained. In this review we want to shed light on the promising application of miRNA-based interventions and provide insights into the specific miRNAs implicated in ovarian cancer pathogenesis.

引用

页数：8

共 102 条

[21] Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? [J].

Filipowicz, Witold ;

Bhattacharyya, Suvendra N. ;

Sonenberg, Nahum .

NATURE REVIEWS GENETICS, 2008, 9 (02) :102-114

[22] Most mammalian mRNAs are conserved targets of microRNAs [J].

Friedman, Robin C. ;

Farh, Kyle Kai-How ;

Burge, Christopher B. ;

Bartel, David P. .

GENOME RESEARCH, 2009, 19 (01) :92-105

[23] Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells [J].

Fu, Xin ;

Tian, Jing ;

Zhang, Lei ;

Chen, Ying ;

Hao, Quan .

FEBS LETTERS, 2012, 586 (09) :1279-1286

[24] MicroRNA as an Important Target for Anticancer Drug Development [J].

Fu, Zhiwen ;

Wang, Liu ;

Li, Shijun ;

Chen, Fen ;

Au-Yeung, Kathy Ka-Wai ;

Shi, Chen .

FRONTIERS IN PHARMACOLOGY, 2021, 12

[25] A synthetic microRNA-92a inhibitor (MRG-110) accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds [J].

Gallant-Behm, Corrie L. ;

Piper, Joseph ;

Dickinson, Brent A. ;

Dalby, Christina M. ;

Pestano, Linda A. ;

Jackson, Aimee L. .

WOUND REPAIR AND REGENERATION, 2018, 26 (04) :311-323

[26] Targeting microRNAs in cancer: rationale, strategies and challenges [J].

Garzon, Ramiro ;

Marcucci, Guido ;

Croce, Carlo M. .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (10) :775-789

[27] CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia [J].

Ge, Pan ;

Zhang, Jian ;

Zhou, Liang ;

Lv, Mo-qi ;

Li, Yi-xin ;

Wang, Jin ;

Zhou, Dang-xia .

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2019, 17 (01)

[28] Accuracy and Effectiveness of Mammography versus Mammography and Tomosynthesis for Population-Based Breast Cancer Screening: A Systematic Review and Meta-Analysis [J].

Giampietro, Rodrigo Rosa ;

Gama Cabral, Marcos Vinicius ;

Molina Lima, Silvana Andrea ;

Theresa Weber, Silke Anna ;

Nunes-Nogueira, Vania dos Santos .

SCIENTIFIC REPORTS, 2020, 10 (01)

[29] Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways [J].

Gomez, Ivan G. ;

MacKenna, Deidre A. ;

Johnson, Bryce G. ;

Kaimal, Vivek ;

Roach, Allie M. ;

Ren, Shuyu ;

Nakagawa, Naoki ;

Xin, Cuiyan ;

Newitt, Rick ;

Pandya, Shweta ;

Xia, Tai-He ;

Liu, Xueqing ;

Borza, Dorin-Bogdan ;

Grafals, Monica ;

Shankland, Stuart J. ;

Himmelfarb, Jonathan ;

Portilla, Didier ;

Liu, Shiguang ;

Chau, B. Nelson ;

Duffield, Jeremy S. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) :141-156

[30]

Gregory RI, 2005, CELL, V123, P631, DOI 10.1016/j.cell.2005.10.022

← 1 2 3 4 5 6 7 8 9 10 →