The recent insight in the release of anticancer drug loaded into PLGA microspheres

被引：11

作者：

Rahmani, Farzad ^{[1
]}

Naderpour, Saghi ^{[2
,3
]}

Nejad, Behnam Ghorbani ^{[4
]}

Rahimzadegan, Milad ^{[3
]}

Ebrahimi, Zivar Nejad ^{[5
]}

Kamali, Hossein ^{[6
,7
]}

Nosrati, Rahim ^{[5
]}

机构：

[1] Islamic Azad Univ, Fac Pharm, Dept Pharmacol & Toxicol, Tehran Med Sci, Tehran, Iran

[2] Eastern Mediterranean Univ, Fac Pharm, Gazimagusa, Cyprus

[3] Shahid Beheshti Univ Med Sci, Funct Neurosurg Res Ctr, Shohada Tajrish Comprehens Neurosurg Ctr Excellenc, Tehran, Iran

[4] Kerman Univ Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Kerman, Iran

[5] Guilan Univ Med Sci, Cellular & Mol Res Ctr, Sch Med, Rasht, Iran

[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut, Mashhad, Iran

来源：

MEDICAL ONCOLOGY | 2023年 / 40卷 / 08期

关键词：

Microspheres; PLGA; Cancer; Drug delivery; Drug release; DELIVERY SYSTEMS; IN-VITRO; BIODEGRADABLE MICROSPHERES; MICROFLUIDIC FABRICATION; PROCESS PARAMETERS; MICROPARTICLES; MECHANISMS; CURCUMIN; THERAPY; BIOAVAILABILITY;

D O I：

10.1007/s12032-023-02103-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a series of diseases leading to a high rate of death worldwide. Microspheres display specific characteristics that make them appropriate for a variety of biomedical purposes such as cancer therapy. Newly, microspheres have the potentials to be used as controlled drug release carriers. Recently, PLGA-based microspheres have attracted exceptional attention relating to effective drug delivery systems (DDS) because of their distinctive properties for a simple preparation, biodegradability, and high capability of drug loading which might be increased drug delivery. In this line, the mechanisms of controlled drug release and parameters that influence the release features of loaded agents from PLGA-based microspheres should be mentioned. The current review is focused on the new development of the release features of anticancer drugs, which are loaded into PLGA-based microspheres. Consequently, future perspective and challenges of anticancer drug release from PLGA-based microspheres are mentioned concisely.

引用

页数：17