Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent

被引：0

作者：

Autio, Timo J. ^{[1
,2
,3
]}

Atula, Timo ^{[4
,5
]}

Jouhi, Lauri ^{[4
,5
]}

Irjala, Heikki ^{[6
,7
]}

Halme, Elina ^{[8
]}

Jouppila-Matto, Anna ^{[9
]}

Makitie, Antti ^{[5
,10
,11
,12
]}

Koivunen, Petri ^{[1
,2
,3
]}

机构：

[1] Oulu Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Oulu, Finland

[2] Univ Oulu, PEDEGO Res Unit, Oulu, Finland

[3] Med Res Ctr Oulu, Oulu, Finland

[4] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Helsinki 00029, Hus, Finland

[5] Helsinki Univ Hosp, Helsinki 00029, Hus, Finland

[6] Turku Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Turku, Finland

[7] Univ Turku, Turku, Finland

[8] Tampere Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Tampere, Finland

[9] Kuopio Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Kuopio, Finland

[10] Univ Helsinki, Fac Med, Res Program Syst Oncol, Helsinki, Finland

[11] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden

[12] Karolinska Univ Hosp, Stockholm, Sweden

来源：

ACTA OTO-LARYNGOLOGICA | 2023年 / 143卷 / 04期

关键词：

Oropharynx; cancer; squamous cell carcinoma; head and neck; human papilloma virus; follow-up; FOLLOW-UP; CANCER; HEAD; SURVIVAL;

D O I：

10.1080/00016489.2023.2188892

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundThe increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers.Aims/objectivesThe aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences.Material and methodsWe analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated.ResultsOut of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months.Conclusions and significanceRoutine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences.

引用

页码：328 / 333

页数：6