The clinicopathological and genetic differences among gastric cancer patients with no recurrence, early recurrence, and late recurrence after curative surgery

被引:7
作者
Chen, Meng-Chao [1 ,2 ]
Su, Hsuan-Yu [3 ,4 ]
Su, Yen-Hao [5 ,6 ,7 ,8 ]
Huang, Kuo-Hung [3 ,4 ,9 ]
Fang, Wen-Liang [3 ,4 ,9 ]
Lin, Chii-Wann [1 ]
Chen, Ming-Huang [4 ,10 ]
Chao, Yee [4 ,10 ]
Lo, Su-Shun [4 ,11 ]
Li, Anna Fen-Yau [4 ,12 ]
Wu, Chew-Wun [3 ,4 ]
机构
[1] Natl Taiwan Univ, Dept Biomed Engn, Taipei, Taiwan
[2] China Med Univ Hosp, Dept Neurosurg, Taipei Branch, Taipei, Taiwan
[3] Taipei Vet Gen Hosp, Dept Surg, Div Gen Surg, 201 Sect 2,Shi Pai Rd, Taipei 112, Taiwan
[4] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan
[5] Taipei Med Univ, Coll Med, Sch Med, Dept Surg, Taipei, Taiwan
[6] Taipei Med Univ, Shuang Ho Hosp, Dept Surg, Div Gen Surg, New Taipei, Taiwan
[7] Taipei Med Univ, Coll Med, Sch Med, Dept Surg,Div Gen Surg, Taipei, Taiwan
[8] Taipei Med Univ, TMU Res Ctr Canc Translat Med, Taipei, Taiwan
[9] Taipei Vet Gen Hosp, Gastr Canc Med Ctr, Dept Surg, Taipei, Taiwan
[10] Taipei Vet Gen Hosp, Ctr Immunooncol, Dept Oncol, Taipei, Taiwan
[11] Natl Yang Ming Chiao Tung Univ Hosp, Dept Surg, Yilan, Taiwan
[12] Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan
关键词
ARID1A; Early recurrence; Gastric cancer; Genetic alteration; Late recurrence; PIK3CA amplification; HELICOBACTER-PYLORI INFECTION; EPSTEIN-BARR-VIRUS; STAGE-II; ARID1A; MUTATION; CHEMOTHERAPY; PREDICTORS; EXPRESSION; RESECTION; PATTERNS;
D O I
10.1097/JCMA.0000000000000846
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background:To date, few reports have investigated the genetic alterations and clinicopathological features among gastric cancer (GC) patients with no tumor recurrence, early recurrence, and late recurrence following curative surgery. Methods:A total of 473 GC patients undergoing curative surgery were included. The clinicopathological characteristics, patient prognosis, recurrence patterns, and genetic alterations were compared between GC patients with early recurrence and late recurrence. Results:Among the 473 GC patients, 119 had early recurrence (<2 years) and 45 had late recurrence (>= 2 years). Patients with early recurrence had tumor size larger than 5 cm, fewer superficial-type tumors, more lymphovascular invasion, more advanced pathological T and N categories and Tumor, Node, Metastasis (TNM) stages, and worse 5-year overall survival than patients with late recurrence and no recurrence. For intestinal-type GC, patients with no tumor recurrence had more Helicobacter pylori infection than patients with early recurrence and late recurrence; for diffuse-type GC patients, the frequency of PIK3CA amplification was the highest in early recurrence, followed by late recurrence and no recurrence. GC patients with single-site recurrence had more ARID1A mutations than those with multiple-site recurrence. Multivariate analysis demonstrated that age, tumor recurrence, and pathological N categories were independent prognostic factors. Conclusion:PIK3CA amplifications were more common in diffuse-type GC with early recurrence, whereas ARID1A mutations were more common in patients with single-site recurrence. Targeted therapy and immunotherapy might be helpful for these patients.
引用
收藏
页码:57 / 64
页数:8
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