Bioactive compounds from Curcuma aeruginosa and the effect of comosone II on the migration and invasion of breast cancer cells

被引：9

作者：

Al-Amin, Mohammad ^{[1
]}

Eltayeb, Nagla Mustafa ^{[1
,2
]}

Hossain, Chowdhury Faiz ^{[3
]}

Rahiman, Siti Sarah Fazalul ^{[1
]}

Khairuddean, Melati ^{[4
]}

Salhimi, Salizawati Muhamad ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Usm, Malaysia

[2] Natl Ctr Res NCR, Trop Med Res Inst TMRI, Khartoum 11111, Sudan

[3] East West Univ, Dept Pharm, Plot A-2, Dhaka 1212, Bangladesh

[4] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Usm, Malaysia

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 03期

关键词：

Curcuma aeruginosa rhizomes; Zingiberaceae; triple-negative breast cancer cells MDA-MB-231; comosone II; cell migration and invasion; matrix metalloproteinases; SESQUITERPENOIDS; RHIZOMES;

D O I：

10.1080/10286020.2022.2081562

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided separation afforded furanodienone 1,10-epoxide (9) as the new compound, curcolone (10) as partially described compound and ten known compounds; germacrone (1), furanodienone (2), curzerenone (3), curcumenol (4), zederone (5), comosone II (6), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone (7), 13-hydroxygermacrone (8), curcuzederone (11) and demethoxycurcumin (12). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of C. aeruginosa rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme. The present study may lead to further anticancer studies of comosone II and supports the traditional uses of C. aeruginosa rhizomes.

引用

页码：252 / 263

页数：12

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