Neural dependency in wound healing and regeneration

被引：4

作者：

Noble, Alexandra ^{[1
]}

Qubrosi, Rozana ^{[1
]}

Cariba, Solsa ^{[1
]}

Favaro, Kayla ^{[1
]}

Payne, Samantha L. ^{[1
,2
]}

机构：

[1] Univ Guelph, Dept Biomed Sci, Guelph, ON, Canada

[2] Univ Guelph, Dept Biomed Sci, 50 Stone Rd East, Guelph, ON N1G 2W1, Canada

来源：

DEVELOPMENTAL DYNAMICS | 2024年 / 253卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

blastema; growth factors; matrix remodeling; neuron; neurotransmitters; reepithelialization; NERVE GROWTH-FACTOR; NEWT LIMB REGENERATION; DIGIT TIP REGENERATION; SUBSTANCE-P; EXTRACELLULAR-MATRIX; BLASTEMA INDUCTION; PROGENITOR CELLS; ADULT NEWT; CARDIOMYOCYTE PROLIFERATION; SUPERNUMERARY LIMBS;

D O I：

10.1002/dvdy.650

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

In response to injury, humans and many other mammals form a fibrous scar that lacks the structure and function of the original tissue, whereas other vertebrate species can spontaneously regenerate damaged tissues and structures. Peripheral nerves have been identified as essential mediators of wound healing and regeneration in both mammalian and nonmammalian systems, interacting with the milieu of cells and biochemical signals present in the post-injury microenvironment. This review examines the diverse functions of peripheral nerves in tissue repair and regeneration, specifically during the processes of wound healing, blastema formation, and organ repair. We compare available evidence in mammalian and nonmammalian models, identifying critical nerve-mediated mechanisms for regeneration and providing future perspectives toward integrating these mechanisms into a therapeutic framework to promote regeneration.

引用

页码：181 / 203

页数：23

共 261 条

[1] Insights regarding skin regeneration in non-amniote vertebrates: Skin regeneration without scar formation and potential step-up to a higher level of regeneration [J].