Novel Two-Step Synthesis of N -Alkylated 2,3-Diaryl-4-quinolones

被引：1
作者：
Aksenov, Alexander V. [1 ]
Arutiunov, Nikolai A. [1 ]
Zatsepilina, Anna M. [1 ]
Aksenova, Anna A. [1 ]
Aleksandrova, Elena V. [1 ]
Aksenov, Nicolai A. [1 ]
Leontiev, Alexander V. [1 ]
Aksenov, Dmitrii A. [1 ]
机构：
[1] North Caucasus Fed Univ, Dept Chem, 1a Pushkin St, Stavropol 355009, Russia
来源：
SYNTHESIS-STUTTGART | 2024年 / 56卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
4-quinolones; indoles; rearrangement; cascade transformations; nitroalkenes; BIOLOGICAL EVALUATION; 4-QUINOLONES; DERIVATIVES; TRANSFORMATION; AGENTS; 2-PHENYL-4-QUINOLONES; 2-ARYL-4-QUINOLONES; CYCLIZATION; APOPTOSIS; ACID;
D O I：
10.1055/s-0042-1751530
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A library of 18 polysubstituted 4-quinolones was conveniently prepared via simple and practical protocol involving N-alkylation of 2-(3-oxoindolin-2-yl)acetonitriles and following NaH-induced ring expansion. The current two-step approach provides feasible access to a subclass of N-protected C3-aryl-substituted 2-phenyl-4-quinolones starting with or just one step away from commercially available 2arylindoles and nitrostyrenes.
引用
收藏
页码：435 / 444
页数：10
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