Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized, double-blinded, placebo-controlled phase 3 trials (ADvocate1 and ADvocate2)

被引:0
|
作者
Blauvelt, Andrew [1 ]
Thyssen, Jacob P. [2 ]
Guttman-Yassky, Emma [3 ]
Bieber, Thomas [4 ]
Carrascosa, Jose Manuel [5 ]
Simpson, Eric [6 ]
Rosmarin, David [7 ]
Elmaraghy, Hany [8 ]
Meskimen, Eric [8 ]
Natalie, Chitra R. [8 ]
Liu, Zhuqing [8 ]
Xu, Chenjia [8 ]
Pierce, Evangeline [8 ]
Morgan-Cox, MaryAnn [8 ]
Silverberg, Jonathan, I [9 ]
机构
[1] Oregon Med Res Ctr, Portland, OR 97223 USA
[2] Univ Copenhagen, Bispebjerg Hosp, Copenhagen, Denmark
[3] Icahn Sch Med Mt Sinai, New York, NY USA
[4] Univ Hosp Bonn, Bonn, Germany
[5] UAB, Germans Trias i Pujol Univ Hosp, IGTP, Barcelona, Spain
[6] Oregon Hlth & Sci Univ, Portland, OR USA
[7] Tufts Univ, Sch Med, Boston, MA USA
[8] Eli Lilly & Co, Indianapolis, IN USA
[9] George Washington Univ, Sch Med & Hlth Sci, Washington, DC USA
关键词
monotherapy; atopic dermatitis; moderate-to-severe; lebrikizumab; interleukin (IL)-13;
D O I
10.1093/bjd/ljac140.018
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
322
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Rocatinlimab Improves Patient-Reported Outcomes in Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Double-Blind Placebo-Controlled Phase 2b Study
    Gooderham, Melinda
    Guttman-Yassky, Emma
    Igawa, Ken
    Kabashima, Kenji
    Esfandiari, Ehsanollah
    Rylands, Angela J.
    Williams, Angela
    Nixon, Annabel
    Dent, Jennifer E.
    Simpson, Eric
    DERMATOLOGY AND THERAPY, 2024, 14 (12) : 3351 - 3366
  • [32] Efficacy and safety of upadacitinib in adults and adolescents with moderate-to-severe atopic dermatitis: subgroup analysis of the Measure Up 1, Measure Up 2 and AD Up phase 3 clinical trials at 52 weeks
    Paller, Amy S.
    Mendes-Bastos, Pedro
    Eichenfield, Lawrence F.
    Soong, Weily
    Lio, Peter
    Prajapati, Vimal H.
    Platt, Andrew M.
    Raymundo, Eliza
    Liu, John
    Ladizinski, Barry
    Thyssen, Jacob P.
    BRITISH JOURNAL OF DERMATOLOGY, 2023, 188
  • [33] Impact of amlitelimab (an anti-OX40 ligand antibody) on clinical outcome assessments for atopic dermatitis: results from the 52-week STREAM-AD phase 2b study in adults with moderate-to-severe atopic dermatitis
    Blauvelt, Andrew
    Chovatiya, Raj
    Merola, Joseph F.
    Weidinger, Stephan
    Igawa, Ken
    Zikos, Efstathios
    Weber, Christine
    Wang, Jennifer
    Gray, Cori
    BRITISH JOURNAL OF DERMATOLOGY, 2024, 191
  • [34] Dupilumab Improves General Health-Related Quality-of-Life in Patients with Moderate-to-Severe Atopic Dermatitis: Pooled Results from Two Randomized, Controlled Phase 3 Clinical Trials
    Eric L. Simpson
    Dermatology and Therapy, 2017, 7 : 243 - 248
  • [35] Dupilumab Improves General Health-Related Quality-of-Life in Patients with Moderate-to-Severe Atopic Dermatitis: Pooled Results from Two Randomized, Controlled Phase 3 Clinical Trials
    Simpson, Eric L.
    DERMATOLOGY AND THERAPY, 2017, 7 (02) : 243 - 248
  • [36] Efficacy and safety of topically applied therapeutic ammonia oxidising bacteria in adults with mild-to-moderate atopic dermatitis and moderate-to-severe pruritus: a randomised, double-blind, placebo-controlled, dose-ranging, phase 2b trial
    Silverberg, Jonathan I.
    Lio, Peter A.
    Simpson, Eric L.
    Li, Connie
    Brownell, Daniel R.
    Gryllos, Ioannis
    Ng-Cashin, Judith
    Krueger, Todd
    Swaidan, Victoria R.
    Bliss, Robin L.
    Kim, Hyun D.
    ECLINICALMEDICINE, 2023, 60
  • [37] Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial
    Guttman-Yassky, Emma
    Brunner, Patrick M.
    Neumann, Avidan U.
    Khattri, Saakshi
    Pavel, Ana B.
    Malik, Kunal
    Singer, Giselle K.
    Baum, Danielle
    Gilleaudeau, Patricia
    Sullivan-Whalen, Mary
    Rose, Sharon
    On, Shelbi Jim
    Li, Xuan
    Fuentes-Duculan, Judilyn
    Estrada, Yeriel
    Garcet, Sandra
    Traidl-Hoffmann, Claudia
    Krueger, James G.
    Lebwohl, Mark G.
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 78 (05) : 872 - +
  • [38] Efficacy of dupilumab treatment in atopic hand and foot dermatitis across morphological subtypes: results from a phase 3, randomized, double-blind, placebo-controlled trial
    Worm, Margitta
    Simpson, Eric L.
    Honari, Golara
    Soong, Weily
    Pinter, Andreas
    Masuda, Koji
    Shao, Liyang
    Dubost-Brama, Ariane
    Bansal, Ashish
    Korotzer, Andrew
    Rossi, Ana B.
    BRITISH JOURNAL OF DERMATOLOGY, 2024, 190 : II60 - II60
  • [39] Efficacy and safety of switching from dupilumab to upadacitinib versus continuous upadacitinib in moderate-to-severe atopic dermatitis: Results from an open-label extension of the phase 3, randomized, controlled trial (Heads Up)
    Blauvelt, Andrew
    Ladizinski, Barry
    Prajapati, Vimal H.
    Laquer, Vivian
    Fischer, Alison
    Eisman, Samantha
    Hu, Xiaofei
    Wu, Tianshuang
    Calimlim, Brian M.
    Kaplan, Blair
    Liu, Yingyi
    Teixeira, Henrique D.
    Liu, John
    Eyerich, Kilian
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2023, 89 (03) : 478 - 485
  • [40] Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial
    Gaborit, Benjamin
    Vanhove, Bernard
    Vibet, Marie-Anne
    Le Thuaut, Aurelie
    Lacombe, Karine
    Dubee, Vincent
    Ader, Florence
    Ferre, Virginie
    Vicaut, Eric
    Orain, Jeremie
    Le Bras, Morgane
    Omnes, Anne
    Berly, Laetitia
    Jobert, Alexandra
    Morineau-Le Houssine, Pascale
    Botturi, Karine
    Josien, Regis
    Flet, Laurent
    Degauque, Nicolas
    Brouard, Sophie
    Duvaux, Odile
    Poinas, Alexandra
    Raffi, Francois
    TRIALS, 2021, 22 (01)