Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

被引：3

作者：

Yoder, A. K. ^{[1
]}

Farooqi, A. S. ^{[1
,6
]}

Wernz, C. ^{[2
]}

Subramaniam, A. ^{[3
]}

Ravi, V. ^{[3
]}

Goepfert, R. ^{[4
]}

Sturgis, E. M. ^{[5
]}

Mitra, D. ^{[1
]}

Bishop, A. J. ^{[1
]}

Guadagnolo, B. A. ^{[1
]}

机构：

[1] MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA

[2] Baylor Coll Med, Houston, TX USA

[3] MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX USA

[4] MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX USA

[5] Baylor Coll Med, Dept Otolaryngol Head & Neck Surg, Houston, TX USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, B2-4860,1515 Holcombe St, Houston, TX 77030 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 08期

关键词：

angiosarcoma; radiation; surgery; PROGNOSIS; RADIOTHERAPY; HEAD;

D O I：

10.1002/hed.27418

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

IntroductionWe investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). MethodsWe conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan-Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. ResultsFor the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. ConclusionLarge or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

引用

页码：1943 / 1951

页数：9

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