Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

被引：2
作者：
Yoder, A. K. [1 ]
Farooqi, A. S. [1 ,6 ]
Wernz, C. [2 ]
Subramaniam, A. [3 ]
Ravi, V. [3 ]
Goepfert, R. [4 ]
Sturgis, E. M. [5 ]
Mitra, D. [1 ]
Bishop, A. J. [1 ]
Guadagnolo, B. A. [1 ]
机构：
[1] MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA
[2] Baylor Coll Med, Houston, TX USA
[3] MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX USA
[4] MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX USA
[5] Baylor Coll Med, Dept Otolaryngol Head & Neck Surg, Houston, TX USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, B2-4860,1515 Holcombe St, Houston, TX 77030 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 08期
关键词：
angiosarcoma; radiation; surgery; PROGNOSIS; RADIOTHERAPY; HEAD;
D O I：
10.1002/hed.27418
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
IntroductionWe investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). MethodsWe conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan-Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. ResultsFor the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. ConclusionLarge or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.
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收藏
页码：1943 / 1951
页数：9
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