Perivascular adipose tissue in vascular pathologies-a novel therapeutic target for atherosclerotic disease?

被引：9

作者：

Adachi, Yusuke ^{[1
]}

Ueda, Kazutaka ^{[1
]}

Takimoto, Eiki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷

基金：

日本学术振兴会;

关键词：

perivascular adipose tissue; beiging; brown adipose tissue; inflammation; atherosclerosis; remodeling; GLUCAGON-LIKE PEPTIDE-1; BEIGE FAT; CARDIOVASCULAR OUTCOMES; COMPUTED-TOMOGRAPHY; RECEPTOR AGONISTS; BROWN; INFLAMMATION; CELL; EMPAGLIFLOZIN; PRDM16;

D O I：

10.3389/fcvm.2023.1151717

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most blood vessels are surrounded by adipose tissues known as perivascular adipose tissue (PVAT). Emerging experimental data have implicated the potential involvement of PVAT in the pathogenesis of cardiovascular disease: PVAT might be a source of inflammatory mediators under pathological conditions such as metabolic disorders, chronic inflammation, and aging, leading to vascular pathologies, while having vasculo-protective roles in a healthy state. PVAT has been also gaining attention in human disease conditions. Recent integrative omics approaches have greatly enhanced our understanding of the molecular mechanisms underlying the diverse functions of PVAT. This review summarizes recent progress in PVAT research and discusses the potential of PVAT as a target for the treatment of atherosclerosis.

引用

页数：7

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