Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells

被引：52

作者：

Varzideh, Fahimeh ^{[1
]}

Gambardella, Jessica ^{[2
]}

Kansakar, Urna ^{[1
]}

Jankauskas, Stanislovas S. ^{[1
]}

Santulli, Gaetano ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Einstein Inst Aging Res, Inst Neuroimmunol & Inflammat INI,Dept Med,Div Car, New York, NY 10461 USA

[2] Albert Einstein Coll Med, Fleischer Inst Diabet & Metab FIDAM, Einstein Mt Sinai Diabet Res Ctr ES DRC, Dept Mol Pharmacol, New York, NY 10461 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CRISPR/Cas9; embryonic stem cell (ESC); epigenetics; histone modifications; human ESC (hESC) vs.~mouse ESC (mESC); Klf4; naive vs.~primed pluripotency; Oct4; pluripotent stem cells (PSC); self-renewal; FIBROBLAST-GROWTH-FACTOR; HUMAN NAIVE PLURIPOTENCY; ACTIVIN-A; MAINTAINS PLURIPOTENCY; TRANSCRIPTION FACTOR; GROUND-STATE; SIGNALING PATHWAYS; CULTURE-CONDITIONS; DNA METHYLATION; FATE DECISIONS;

D O I：

10.3390/ijms24098386

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as "self-renewal", and to differentiate into different cell types, a peculiar characteristic known as "pluripotency". Self-renewal and pluripotency of ESCs are finely orchestrated by precise external and internal networks including epigenetic modifications, transcription factors, signaling pathways, and histone modifications. In this systematic review, we examine the main molecular mechanisms that sustain self-renewal and pluripotency in both murine and human ESCs. Moreover, we discuss the latest literature on human naive pluripotency.

引用

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