A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications

被引:34
作者
Allu, Ishita [1 ]
Kumar Sahi, Ajay [2 ]
Kumari, Pooja [3 ]
Sakhile, Karunya [4 ]
Sionkowska, Alina [2 ,5 ]
Gundu, Shravanya [1 ]
机构
[1] Osmania Univ, Univ Coll Engn UCE, Dept Biomed Engn, Hyderabad 500007, Telangana, India
[2] Nicolaus Copernicus Univ Torun, Fac Chem, Jurija Gagarina 11, PL-87100 Torun, Poland
[3] Banaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Tissue Engn & Biomicrofluid Lab, Varanasi 221005, Uttar Pradesh, India
[4] Natl Univ Sci & Technol, Dept Mech & Ind Engn, Muscat 2322, Oman
[5] Calisia Univ, Fac Hlth Sci, Nowy Swiat 4, PL-62800 Kalisz, Poland
关键词
wound healing; cerium oxide; skin; scaffolds; NANOPARTICLES; TISSUE; ANGIOGENESIS; HYDROGEL; CELLS; SKIN; PCL;
D O I
10.3390/mi14040865
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The process of wound healing is complex and involves the interaction of multiple cells, each with a distinct role in the inflammatory, proliferative, and remodeling phases. Chronic, nonhealing wounds may result from reduced fibroblast proliferation, angiogenesis, and cellular immunity, often associated with diabetes, hypertension, vascular deficits, immunological inadequacies, and chronic renal disease. Various strategies and methodologies have been explored to develop nanomaterials for wound-healing treatment. Several nanoparticles such as gold, silver, cerium oxide and zinc possess antibacterial properties, stability, and a high surface area that promotes efficient wound healing. In this review article, we investigate the effectiveness of cerium oxide nanoparticles (CeO(2)NPs) in wound healing-particularly the effects of reducing inflammation, enhancing hemostasis and proliferation, and scavenging reactive oxygen species. The mechanism enables CeO(2)NPs to reduce inflammation, modulate the immunological system, and promote angiogenesis and tissue regeneration. In addition, we investigate the efficacy of cerium oxide-based scaffolds in various wound-healing applications for creating a favorable wound-healing environment. Cerium oxide nanoparticles (CeO(2)NPs) exhibit antioxidant, anti-inflammatory, and regenerative characteristics, enabling them to be ideal wound healing material. Investigations have shown that CeO(2)NPs can stimulate wound closure, tissue regeneration, and scar reduction. CeO(2)NPs may also reduce bacterial infections and boost wound-site immunity. However, additional study is needed to determine the safety and efficacy of CeO(2)NPs in wound healing and their long-term impacts on human health and the environment. The review reveals that CeO(2)NPs have promising wound-healing properties, but further study is needed to understand their mechanisms of action and ensure their safety and efficacy.
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页数:19
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