Antibody dependent disease enhancement (ADE) after COVID-19 vaccination and beta glucans as a safer strategy in management

被引：15

作者：

Ikewaki, Nobunao ^{[1
,2
]}

Kurosawa, Gene ^{[3
,4
]}

Levy, Gary A. ^{[5
]}

Preethy, Senthilkumar ^{[6
]}

Abraham, Samuel J. K. ^{[7
,8
,9
,10
]}

机构：

[1] Kyushu Univ Hlth & Welf, Dept Med Life Sci, Nobeoka, Miyazaki, Japan

[2] Junsei Educ Inst, Inst Immunol, Nobeoka, Miyazaki, Japan

[3] Fujita Hlth Univ, Ctr Res Promot & Support, Dept Acad Res Support Promot Facil, Toyoake, Aichi, Japan

[4] MabGenesis KK, Nagoya, Japan

[5] Univ Toronto, Med & Immunol, Toronto, ON, Canada

[6] Fujio Eiji Acad Terrain FEAT, Nichi In Ctr Regenerat Med NCRM, Chennai, India

[7] Univ Yamanashi, Ctr Adv Clin Res CACR, Sch Med, Chuo, Japan

[8] Nichi In Ctr Regenerat Med NCRM, Mary Yoshio Translat Hexagon MYTH, Chennai, India

[9] GN Corp Co Ltd, Antony Xavier Interdisciplinary Scholast AXIS, Kofu, Japan

[10] 3-8 Wakamatsu, Kofu, Yamanashi 4000866, Japan

来源：

VACCINE | 2023年 / 41卷 / 15期

关键词：

COVID-19; SARS-CoV2; Vaccine Antibody-dependent disease enhancement (ADE); Beta-glucan; ACUTE RESPIRATORY SYNDROME;

D O I：

10.1016/j.vaccine.2023.03.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A potential risk associated with vaccines for COVID-19 is antibody-dependent disease enhancement (ADE) in which vaccine induced antibody mediated immune responses may lead to enhanced SARS CoV-2 acquisition or increased disease severity. Though ADE has not been clinically demonstrated with any of the COVID-19 vaccines so far, when neutralizing antibodies are suboptimal, the severity of COVID-19 has been reported to be greater. ADE is presumed to occur via abnormal macrophages induced by the vaccine based immune response by antibody-mediated virus uptake into Fc gamma receptor IIa (FccRIIa) or by the formation of Fc-mediated excessive antibody effector functions. Beta-glucans which are naturally occurring polysaccharides known for unique immunomodulation by capability to interact with macrophages, eliciting a specific beneficial immune-response and enhancing all arms of the immune system, importantly without over-activation are suggested as safer nutritional supplement-based vaccine adjuvants for COVID-19. (C) 2023 Elsevier Ltd. All rights reserved.

引用

页码：2427 / 2429

页数：3

共 30 条

[1]

[Anonymous], NEW YORK TIMES

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