Increased GS-II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps

被引：1

作者：

Matoba, Hisanori ^{[1
,5
]}

Iwaya, Mai ^{[2
]}

Sato, Yoshiko ^{[1
]}

Kobayashi, Noriyasu ^{[3
]}

Takemura, Haruka ^{[3
]}

Kouno, Yusuke ^{[4
]}

Karasawa, Ayumi ^{[4
]}

Nakayama, Jun ^{[1
]}

机构：

[1] Shinshu Univ, Dept Mol Pathol, Sch Med, Matsumoto, Japan

[2] Shinshu Univ Hosp, Dept Lab Med & Pathol, Matsumoto, Japan

[3] JA North Alps Med Ctr Azumi Hosp, Dept Lab Med, Oaza Ikeda, Japan

[4] Ina Cent Hosp, Dept Pathol, Koshiroukubo, Ina, Japan

[5] Shinshu Univ, Dept Mol Pathol, Sch Med, Asahi 3 1 1, Matsumoto 3908621, Japan

来源：

PATHOLOGY INTERNATIONAL | 2023年 / 73卷 / 06期

基金：

日本学术振兴会;

关键词：

GS-II; microvesicular hyperplastic polyps; SATB2; sessile serrated lesions; beta GlcNAc; ISLAND METHYLATOR PHENOTYPE; BRAF MUTATION; EXPRESSION; CARCINOMA; SPECIFICITY; AGGLUTININ; PATHWAY; CANCERS; ADENOMA; PROTEIN;

D O I：

10.1111/pin.13321

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Sessile serrated lesions (SSLs) and microvesicular hyperplastic polyps (MVHPs) are colorectal lesions displaying gastric differentiation. Griffonia simplicifolia-II (GS-II) is a lectin specific to terminal alpha/beta GlcNAc residues. Here, we assessed GS-II binding and performed immunostaining for HIK1083 (specific to terminal alpha GlcNAc residues), MUC5AC, MUC6, and special AT-rich sequence binding protein 2 (SATB2) in SSLs, MVHPs, and tubular adenomas (TAs). We observed MUC5AC positivity in 28 of 30 SSLs, but in only three of 23 TAs. Moreover, 24 of 30 SSLs were MUC6-positive, while none of the 23 TAs were MUC6-positive. None of the 30 SSLs or 23 TAs showed HIK1083 positivity. All 30 SSLs and 26 MVHPs were GS-II-positive, while only seven of 23 were in TAs. GS-II staining was mainly distributed in the Golgi region, but SSLs and MVHPs showed goblet cell distribution, in 20 of 30 and 19 of 26 cases, respectively. All SSLs, MVHPs, and TAs were SATB2-positive, but 21 of 30 SSLs and 12 of 26 MVHPs showed decreased staining intensity relative to adjacent mucosa, a decrease seen in only two of 23 in TAs. These results indicate overall that increased terminal beta GlcNAc and decreased SATB2 expression are characteristics of SSLs and MVHPs.

引用

页码：246 / 254

页数：9